{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T08:39:38Z","timestamp":1781944778427,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold> To determine the associations between preterm delivery &lt;37\u2003weeks (PTD), cervical fluid interleukin\u20101<jats:italic>\u03b2<\/jats:italic> (IL\u20101<jats:italic>\u03b2<\/jats:italic>) concentration, and its +3953 single nucleotide polymorphism (SNP).<\/jats:p><jats:p><jats:bold>Method of Study\u2002<\/jats:bold> Cervical fluid, peripheral blood, and cord blood samples were obtained from a cohort of women 23\u201332\u2003weeks gestation with preterm labor symptoms and intact membranes.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Increased cervical fluid concentrations of IL\u20101<jats:italic>\u03b2<\/jats:italic> were associated with PTD (<jats:italic>P<\/jats:italic>\u2003=\u20030.017) and spontaneous PTD (<jats:italic>P<\/jats:italic>\u2003=\u20030.001). Maternal IL\u20101<jats:italic>\u03b2<\/jats:italic> +3953 SNP genotype was associated neither with PTD (<jats:italic>P<\/jats:italic>\u2003=\u20030.43) nor with cervical fluid IL\u20101<jats:italic>\u03b2<\/jats:italic> concentrations (<jats:italic>P<\/jats:italic>\u2003=\u20030.35). Neonatal IL\u20101<jats:italic>\u03b2<\/jats:italic> +3953 SNP genotype was associated neither with PTD nor cervical IL\u20101<jats:italic>\u03b2<\/jats:italic> concentrations.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Cervical fluid concentrations of IL\u20101<jats:italic>\u03b2<\/jats:italic> were elevated in symptomatic women destined to have a spontaneous PTD. The gene dosage of maternal IL\u20101<jats:italic>\u03b2<\/jats:italic> +3953 allele 2 was associated neither with increased cervical fluid concentrations of IL\u20101<jats:italic>\u03b2<\/jats:italic> nor with risk of PTD.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2005.00358.x","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T14:42:05Z","timestamp":1141828925000},"page":"259-264","source":"Crossref","is-referenced-by-count":16,"title":["The Interleukin\u20101\u03b2 +3953 Single Nucleotide Polymorphism: Cervical Protein Concentration and Preterm Delivery Risk"],"prefix":"10.1111","volume":"55","author":[{"given":"Rodney K.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Duff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,8]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1","article-title":"Births: final data for 2002","volume":"52","author":"Martin JA","year":"2003","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.6.1215"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70347-0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/6.1.51"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90172-5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1992.tb00737.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70058-4"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70180-6"},{"key":"e_1_2_6_10_2","first-page":"565","article-title":"The interleukin\u20101 family","volume":"9","author":"Roux\u2010Lombard P","year":"1998","journal-title":"Eur Cytokine Netw"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01480.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02370.x"},{"key":"e_1_2_6_14_2","first-page":"606","article-title":"Novel genetic association of an IL\u20101\u03b2 gene variation at +3953 with IL\u20101\u03b2 protein production and psoriasis","volume":"7","author":"Giovine FS","year":"1995","journal-title":"Cytokine"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380140069024"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb14497.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91360-2"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512283332604"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.4.4.485"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/164.1.88"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.10.590"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.2.297-301.1991"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-002-0935-x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.11.007"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gag076"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122407"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0897.2005.00358.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0897.2005.00358.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T21:53:52Z","timestamp":1697406832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0897.2005.00358.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,8]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1111\/j.1600-0897.2005.00358.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0897.2005.00358.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,8]]}}}