{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:55:05Z","timestamp":1789786505718,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>To determine the effects of macrophage on endometrial stromal cells (ESCs) in women with adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Eutopic endometrium was obtained and separated into single ESC in 10 women with adenomyosis (study group) and 11 without adenomyosis (control group). ESCs were then cultured alone or with macrophage for 24\u2003hr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunohistochemistry identified the presence of interleukin\u20106 (IL\u20106), IL\u20108, and IL\u201010 in ESCs. Real\u2010time quantitative PCR revealed that the IL\u20106 mRNA was significantly expressed in macrophage\u2010cocultured ESCs in adenomyosis than that in the controls, but was not different in ESCs cultured alone between the two groups. The levels of IL\u20108 and IL\u201010 mRNA were similar in ESCs either cultured alone or with macrophage between women with and without adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u20106 mRNA was significantly expressed in ESCs after <jats:italic>in vitro<\/jats:italic> coculture with macrophage in adenomyosis. This aberrant behavior of ESCs might play a role in the formation of ectopic endometrial implants in adenomyosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2005.00363.x","type":"journal-article","created":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T16:32:11Z","timestamp":1138811531000},"page":"181-187","source":"Crossref","is-referenced-by-count":39,"title":["Increased Interleukin\u20106 Messenger RNA Expression in Macrophage\u2010Cocultured Endometrial Stromal Cells in Adenomyosis"],"prefix":"10.1111","volume":"55","author":[{"given":"Jehn\u2010Hsiahn","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Yih","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daw\u2010Yuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Huei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Shih","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Nerng","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh372"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.4.312"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.4.360"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56456-5"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0897.2003.01207.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136306"},{"key":"e_1_2_7_8_2","first-page":"729","article-title":"Up\u2010regulation of tumor interleukin\u20108 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non\u2010small cell lung cancer","volume":"9","author":"Chen JJ","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03334-4"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2004.00201.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.5.2320"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh193"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00062-4"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.5.696"},{"key":"e_1_2_7_15_2","first-page":"4625","article-title":"Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma","volume":"56","author":"Leek RD","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.2.824"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00496-3"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.53.5.602"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(96)88352-5"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.8.3092"},{"key":"e_1_2_7_21_2","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.4049\/jimmunol.142.9.3134","article-title":"Cytokine\u2010induced production of IFN\u2010beta 2\/IL\u20106 by freshly explanted human endometrial stromal cells. 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