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A selection of these patients would be advantageous for higher efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>A complex immunological panel assay was offered to patients with reproductive failure without any other known cause. We focused here on the cellular immunological parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High cytotoxic T lymphocyte precursor frequency and cell\u2010mediated cytotoxic activity and a rather high natural killer cell activity were found in alloimmune RSA patients. Thirty\u2010two patients were investigated by immunological assays and in 78% of the women an alloimmune background could be defined. The efficacy of IVIG treatment was 96% in this group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel cellular immunological assays proved to be favourable for the indication of RSA patients and showed the usefulness of this selection process for effective immunotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2006.00368.x","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T15:27:27Z","timestamp":1143732447000},"page":"331-340","source":"Crossref","is-referenced-by-count":22,"title":["Alloimmune and Autoimmune Background in Recurrent Pregnancy Loss \u2013 Successful Immunotherapy by Intravenous 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