{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:22:54Z","timestamp":1774520574055,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T00:00:00Z","timestamp":1146614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Interleukin (IL)\u201018 is a novel cytokine, previously known as interferon (IFN)\u2010<jats:italic>\u03b3<\/jats:italic> inducing factor. We evaluated the levels of IL\u201018 and IFN\u2010<jats:italic>\u03b3<\/jats:italic> in seminal plasma (SP) of fertile and infertile men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Semen samples were obtained by masturbation from 80 men, and were examined for the levels of IL\u201018 and IFN\u2010<jats:italic>\u03b3<\/jats:italic> by enzyme\u2010linked immunosorbent assay. Seven groups were included: (i) fertile men (<jats:italic>n<\/jats:italic>\u2003=\u200318), (i) infertile men with genital tract infections (<jats:italic>n<\/jats:italic>\u2003=\u200317), (iii) with varicocele (<jats:italic>n<\/jats:italic>\u2003=\u200315), (iv) with Klinefelter syndrome (<jats:italic>n<\/jats:italic>\u2003=\u20036), (v) with cryptorchidism (<jats:italic>n<\/jats:italic>\u2003=\u20037), (vi) with mumps orchitis (<jats:italic>n<\/jats:italic>\u2003=\u20037), and (vii) with idiopathic testicular lesions (<jats:italic>n<\/jats:italic>\u2003=\u200310).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean levels of IL\u201018 were higher in SP from infertile men with genital tract infections compared with SP from other groups except Klinefelter syndrome (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). However, no significant differences could be detected for IFN\u2010<jats:italic>\u03b3<\/jats:italic>. A significant positive correlations was found between IL\u201018 and IFN\u2010<jats:italic>\u03b3<\/jats:italic> in total patient population (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Moreover, a negative correlation was observed between IL\u201018 and sperm concentrations, and motility (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01 and &lt;0.03, respectively). Furthermore, there was a positive and statistically significant association between IL\u201018 and IFN\u2010<jats:italic>\u03b3<\/jats:italic> levels in SP of infertile men with genital tract infections (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). However, there was no relationship between IL\u201018 and IFN\u2010<jats:italic>\u03b3<\/jats:italic>, and semen parameters in the same group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SP IL\u201018 levels were increased in men with urogenital infections. Thus, the elevated expression of IL\u201018 in SP may be used as a diagnostic marker in the male genital tract infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2006.00380.x","type":"journal-article","created":{"date-parts":[[2006,5,4]],"date-time":"2006-05-04T00:49:06Z","timestamp":1146703746000},"page":"428-433","source":"Crossref","is-referenced-by-count":46,"title":["Increased IL\u201018 Levels in Seminal Plasma of Infertile Men with Genital Tract Infections"],"prefix":"10.1111","volume":"55","author":[{"given":"Ioannis 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