{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:35:59Z","timestamp":1767839759260,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:00:00Z","timestamp":1156464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold> To investigate the Th1\/Th2 cytokine changes in abortion\u2010prone recipient mice adoptively transferred by the paternal antigen\u2010hyporesponsive T cells.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> The paternal antigen\u2010hyporesponsive T cells were generated by the anti\u2010B7 monoclonal antibody (mAb) treatment and adoptively transferred into pregnant CBA\/J mice of abortion\u2010prone matings on day 4 of gestation. The intracellular expressions of Th1 cell\u2010derived cytokine, tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic>, <jats:italic>\u03b3<\/jats:italic>\u2010interferon and interleukin\u20102 (IL\u20102) and Th2 cell\u2010derived cytokine, IL\u20104 and IL\u201010 in the maternal spleen were analyzed by flow cytometry, and secretions of the Th1 and Th2 cytokines in supernatant of the feto\u2010placental unit culture were analyzed by an enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Our findings showed the increased secretion of Th1 cytokines and the decreased secretion of Th2 cytokines in abortion\u2010prone matings. Treatment with anti\u2010B7 mAbs on day 4 of gestation enhanced Th2 and reduced Th1 cytokine production in abortion\u2010prone matings. Similarly, adoptive transfer of paternal antigen\u2010hyporesponsive T cells induced maternal tolerance to the fetus and displayed a Th2 bias both in the peripheral lymphocytes and at the materno\u2010fetal interface of the abortion\u2010prone matings.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> These findings indicate that the Th2 cytokine bias and an increase in fetal viability induced by the anti\u2010B7 mAb treatment can be transferred to other pregnant mice of the abortion\u2010prone matings.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2006.00425.x","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T14:39:43Z","timestamp":1156516783000},"page":"258-266","source":"Crossref","is-referenced-by-count":15,"title":["Adoptive Transfer of Paternal Antigen\u2010Hyporesponsive T Cells Facilitates a Th2 Bias in Peripheral Lymphocytes and at Materno\u2010Fetal Interface in Murine Abortion\u2010prone 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