{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:11:25Z","timestamp":1771333885177,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T00:00:00Z","timestamp":1162252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold> Autoimmune mechanisms are involved in etiology of female infertility, the medical problem frequently treated by <jats:italic>in vitro<\/jats:italic> fertilization (IVF). Controlled ovarian hyperstimulation (COH) with supraphysiological levels of sex hormones is achieved by IVF.<\/jats:p><jats:p><jats:bold>Methods of study\u2002<\/jats:bold> Anti\u2010human\u2010ovary and eight common autoantibodies [nuclear (ANA\u2010H, ANA\u2010R on human HEp\u20102 cell line and rodent antigen, respectively), smooth muscle (SMA), parietal cell, thyroid microsomal, mitochondrial, <jats:italic>\u03b2<\/jats:italic>2\u2010glycoprotein\u2010I, cardiolipin antibodies] found in IVF patients (<jats:italic>n<\/jats:italic>\u2003= 129) were analyzed with regard to the number of previous IVF procedures and the age of the patient. The changes in autoimmune reactions caused by the COH were determined.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Endometriosis and polycystic ovary syndrome were associated with a higher number of common serum autoantibodies compared with the tubal factor infertility (Proportion test, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). ANA\u2010R was associated with unexplained infertility [adjusted odds ratio (aOR) 8.79, <jats:italic>P<\/jats:italic>\u2003=\u20030.038]. SMA correlated with endometriosis (aOR 37.29, <jats:italic>P<\/jats:italic>\u2003=\u20030.008), male factor infertility (aOR 20.45, <jats:italic>P<\/jats:italic>\u2003=\u20030.018) and with the previous IVF procedures (aOR 2.87, <jats:italic>P<\/jats:italic>\u2003=\u20030.013). There was an overall decrease in the number of detectible autoantibodies after COH (Proportion test, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> COH may have a suppressive effect on the humoral immunity by the time of embryo transfer but more conclusive studies are needed.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2006.00438.x","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T14:08:57Z","timestamp":1162303737000},"page":"364-370","source":"Crossref","is-referenced-by-count":14,"title":["Controlled Ovarian Hyperstimulation Changes the Prevalence of Serum Autoantibodies in <i>In Vitro<\/i> Fertilization 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