{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:03:10Z","timestamp":1762160590115},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T00:00:00Z","timestamp":1170806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>We have previously demonstrated the presence of naturally occurring antibodies against follicle\u2010stimulating hormone (FSH) in patients with endometriosis and polycystic ovary syndrome (PCOS). Here, we investigated the parameters associated with anti\u2010FSH antibodies in <jats:italic>in vitro<\/jats:italic> fertilization (IVF) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods of study<\/jats:title><jats:p>The following parameters were studied in 135 patients: peripheral FSH levels, FSH <jats:italic>\u03b2<\/jats:italic>\u2010subunit gene (<jats:italic>FSHB<\/jats:italic>) haplotypes, history of previous IVF, and susceptibility to autoimmune reactions in general [seven common autoantibodies (against nuclear antigens on human and rodent substrates, smooth muscle, gastric parietal cells, <jats:italic>\u03b2<\/jats:italic>2\u2010glycoprotein I, cardiolipin, and thyroid peroxidase) and <jats:italic>HLA\u2010DQB1<\/jats:italic> alleles].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although the anti\u2010FSH levels were higher in patients when compared with controls, those higher levels were not associated with <jats:italic>FSHB<\/jats:italic> haplotypes. The anti\u2010FSH IgM associated with (i) the levels of FSH in women with male and tubal factor infertility; (ii) the history of IVF in patients with PCOS, endometriosis, and unexplained infertility; and (iii) the production of common autoantibodies among all IVF patients. The anti\u2010FSH IgA associated with <jats:italic>HLA\u2010DQB1*03.<\/jats:italic> The anti\u2010FSH IgG correlated with the values of anti\u2010FSH IgA and IgM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010FSH may be naturally occurring antibodies associated with peripheral FSH concentrations, but increased in infertile women with dysregulation of immune reactions and repeatedly performed IVF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2006.00462.x","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T15:48:45Z","timestamp":1170863325000},"page":"193-200","source":"Crossref","is-referenced-by-count":19,"title":["Putative Predictors of Antibodies Against Follicle\u2010Stimulating Hormone in Female Infertility: A Study Based on <i>In Vitro<\/i> Fertilization 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