{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:29:13Z","timestamp":1791084553586,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T00:00:00Z","timestamp":1173744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Soluble (s) HLA\u2010G1\/G5 molecules may potentially affect immune homeostasis during pregnancy. The aim of this study was to determine changes of sHLA\u2010G1\/G5 plasma levels throughout normal pregnancy and to assess its predictive value for the occurrence of characteristic gestation\u2010associated diseases during further course of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>sHLA\u2010G1\/G5 levels were estimated in plasma samples of 40 non\u2010pregnant women, 291 women throughout normal pregnancy and 236 women affected by different complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison with non\u2010pregnant women sHLA\u2010G1\/G5 levels strongly increased during the first trimenon and then decreased continuously toward term. Non\u2010parametric discriminant analysis showed that women with significantly decreased sHLA\u2010G1\/G5 levels in the second trimenon had an increased risk of developing preeclampsia and\/or intrauterine growth retardation (IUGR) during further course of pregnancy. However, in the third trimenon, sHLA\u2010G1\/G5 levels in affected women did not deviate significantly from those of non\u2010affected women. Surprisingly, significantly increased sHLA\u2010G1\/G5 levels were detected in third trimenon women with uncontrollable preterm labor, but not in women with prolonged preterm rupture of fetal membranes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For the identification of women with an increased risk of IUGR and\/or preeclampsia, measurement of sHLA\u2010G1\/G5 plasma levels may be a powerful new tool in prenatal diagnostics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2007.00475.x","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T07:11:12Z","timestamp":1173769872000},"page":"277-286","source":"Crossref","is-referenced-by-count":82,"title":["Early Detection of Decreased Soluble HLA\u2010G Levels in the Maternal Circulation Predicts the Occurrence of Preeclampsia and Intrauterine Growth Retardation During Further Course of 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