{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:21:10Z","timestamp":1767972070990,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,25]],"date-time":"2007-04-25T00:00:00Z","timestamp":1177459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>In consideration of the effect of adenosine deaminase (ADA) and ACP1 (a low\u2010molecular\u2010weight protein tyrosine phosphatase) on T\u2010cell receptor activity, we have analysed the joint distribution of these polymorphisms in a sample of women with primary repeated spontaneous abortion (RSA) to search for possible interactive effects on susceptibility to RSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>ACP1 and ADA phenotypes were determined in 170 women with primary RSA in 79 healthy consecutive puerperae and in 160 female newborns from the Caucasian population of Rome and in 357 healthy consecutive puerperae from the Caucasian population of Penne. Chi\u2010square test of independence and three way contingency table analysis by a log\u2010linear model were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with low\u2010ADA activity and high\u2010ACP1 activity show the lowest susceptibility to RSA. Women with high\u2010ADA activity and low\u2010ACP1 activity, on the contrary, show the highest susceptibility to RSA and also the highest incidence of auto antibodies and of A blood group incompatibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data are in agreement with those expected on the basis of the effects of ACP1 and ADA genetic variability on T\u2010cell receptor activity and suggest a cooperative effect of the two polymorphic systems in the susceptibility\/resistance to repeated spontaneous abortion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2007.00483.x","type":"journal-article","created":{"date-parts":[[2007,5,6]],"date-time":"2007-05-06T16:54:51Z","timestamp":1178470491000},"page":"1-10","source":"Crossref","is-referenced-by-count":8,"title":["Repeated Spontaneous Abortion. 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