{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:36:40Z","timestamp":1791175000684,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T00:00:00Z","timestamp":1177632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>To determine the value of leukemia inhibitory factor (LIF) assessment for predicting the reproductive outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Two phase study. Phase I: assessment of LIF in uterine flushing. Phase II: 1,5\u2003years after examining the last patient, a questionnaire was sent to all participants of the phase I. Phase I: Uterine flushing and endometrial samples were collected during implantation window from infertile patients with stage I\/II endometriosis (<jats:italic>n<\/jats:italic>\u2003=\u200314), patients with idiopathic infertility (<jats:italic>n<\/jats:italic>\u2003=\u200327), luteal phase deficiency (<jats:italic>n<\/jats:italic>\u2003=\u200313), and fertile control (<jats:italic>n<\/jats:italic>\u2003=\u200321). LIF was assessed in uterine flushings in all patients by ELISA. In endometrium, semiquantitative RT\u2010PCR was performed for LIF mRNA expression. Phase II: questionnaire has been sent to all infertile women taking part in the first phase of the experiment, regarding their reproductive outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>65.4% patients who had returned the questionnaire did get pregnant. LIF concentration at a cut\u2010off point of 2.31\u2003pg\/ml had a 95.7% sensitivity and 81.8% specificity in predicting the reproductive outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This prospective study for the first time in literature indicates that the LIF assessment can be used as a predictor of reproductive success.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2007.00492.x","type":"journal-article","created":{"date-parts":[[2007,5,7]],"date-time":"2007-05-07T02:02:21Z","timestamp":1178503341000},"page":"65-74","source":"Crossref","is-referenced-by-count":46,"title":["The Impact of Leukemia Inhibitory Factor in Uterine Flushing on the Reproductive Potential of Infertile Women \u2013 A Prospective 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