{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:00:26Z","timestamp":1760266826397},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,10,7]],"date-time":"2007-10-07T00:00:00Z","timestamp":1191715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Interleukin (IL) IL\u201012\/IL\u201018 are involved in uterine NK cells control of uterine vascular development. Polymorphisms in the IL\u201012\/IL\u201018 genes could modify the cytokine balance, which might result in an increased susceptibility to recurrent spontaneous abortion (RSA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>A case\u2013control study was conducted to determine the association between the IL12 (I\/D) and IL18 (<jats:italic>\u2212607C&gt;A<\/jats:italic>, <jats:italic>\u2212137G&gt;C<\/jats:italic>) gene polymorphisms and the risk of RSA in 125 women with RSA and in 136 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of DD, ID, II for IL\u201012 were, 25.6%, 52.8% and 21.6% respectively, in patients <jats:italic>versus<\/jats:italic> 21.3%, 51.5% and 27.2% respectively in controls; the frequencies of CC, CA, AA genotypes for IL\u201018 (\u2212607) were, 34.4%, 54.4% and 11.2% respectively in patients <jats:italic>versus<\/jats:italic> 30.1%, 58.1% and 11.8% respectively in controls; the frequencies of GG, GC, CC genotypes for IL\u201018(\u2212137) were 47.2%, 43.2% and 9.6% respectively in patients and 45.6%, 46.3% and 8.1% respectively in controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u201012B and IL\u201018 promoter gene polymorphisms were not associated with RSA in our women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2007.00501.x","type":"journal-article","created":{"date-parts":[[2007,10,8]],"date-time":"2007-10-08T01:23:03Z","timestamp":1191806583000},"page":"403-408","source":"Crossref","is-referenced-by-count":18,"title":["Polymorphisms in the Interleukin\u201012\/18 Genes and Recurrent Spontaneous 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