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Clinical symptoms may include pelvic pain, dysmenorrhea, dyspareunia, pelvic\/abdominal masses, and infertility. Symptomatic treatments such as surgical resection and\/or hormonal suppression of ovarian function and analgesics are not as effective as desired. Consequently, there is an enormous unmet need to develop effective medical therapy capable of preventing the occurrence and recurrence of EMS without undesirable side\u2010effects. EMS\u2010associated intra\u2010abdominal bleeding episodes, local inflammation, adhesions, and i.p. immunologic dysfunction leads to pelvic nociception and pelvic pain. Increasing evidence supports the involvement of allergic\u2010type inflammation in EMS. Invasion of mast cells, degranulation, and proliferation of interstitial component are observed in endometriotic lesions. Presence of activated and degranulating mast cells within the nerve structures can contribute to the development of pain and hyperalgesia by direct effects on primary nociceptive neurons. Therefore, treatments targeting endometrial mast cells may prove effective in preventing or alleviating EMS\u2010associated symptoms. The Janus kinase 3 (JAK3) is abundantly expressed in mast cells and is required for the full expression of high\u2010affinity IgE receptor\u2010mediated mast cell inflammatory sequelae. JANEX\u20101\/WHI\u2010P131 is a rationally designed novel JAK3 inhibitor with potent anti\u2010inflammatory activity in several cellular and<jats:italic>in vivo<\/jats:italic>animal models of inflammation, including mouse models of peritonitis, colitis, cellulitis, sunburn, and airway inflammation with favorable toxicity and pharmacokinetic profile. 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