{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:53:07Z","timestamp":1769763187781,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T00:00:00Z","timestamp":1188950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Inflammatory changes frequently occur in cases of second trimester miscarriage or pre\u2010term delivery, but little attention has been paid to this association with recurrent miscarriage. As interleukin\u20106 and interleukin\u20108 are inflammatory cytokines reported to be associated with bacterial vaginosis, intrauterine infections, and pre\u2010term delivery, we here investigated whether they might have predictive value for spontaneous abortion in recurrent cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Cervical mucus and sera were collected at 4\u20135\u2003weeks\u2019 gestation from a total of 59 patients with a history of two or more unexplained consecutive first trimester miscarriages, and examined by enzyme\u2010linked immunosorbent assay. Patients then were followed up without medication and their pregnancy outcomes were compared with the test results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of a total of 59 patients, 13 (22%) miscarried subsequently. Both IL\u20106 and IL\u20108 in cervical mucus were significantly higher in patients who miscarried subsequently than in those who had a live birth. In addition, there was no correlation between cervical mucus and serum concentrations of IL\u20106 and IL\u20108 take at the same time, and there was no relation with serum IL\u20106 and IL\u20108 levels between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cervical IL\u20106 and IL\u20108 might have predictive value for cases of recurrent miscarriage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2007.00516.x","type":"journal-article","created":{"date-parts":[[2007,9,8]],"date-time":"2007-09-08T05:25:00Z","timestamp":1189229100000},"page":"350-357","source":"Crossref","is-referenced-by-count":34,"title":["Uterine Cervical Inflammatory Cytokines, Interleukin\u20106 and \u20108, as Predictors of Miscarriage in Recurrent 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