{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:25:44Z","timestamp":1776821144386,"version":"3.51.2"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,10,24]],"date-time":"2008-10-24T00:00:00Z","timestamp":1224806400000},"content-version":"vor","delay-in-days":266,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The association between 60\u2003kDa <jats:italic>Chlamydia trachomatis<\/jats:italic> heat shock protein (CHSP60) antibodies and the etiology and outcomes of <jats:italic>in vitro<\/jats:italic> fertilization (IVF) outcomes is not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>A retrospective study with a double\u2010blind analysis of follicular fluid from 253 IVF patients for IgG antibodies to CHSP60.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CHSP60 antibodies were detected in 74.1% of women without embryo implantation and in 47.9% of women with 1\u20133 implantations per IVF cycle (<jats:italic>P<\/jats:italic>\u2003=\u20030.0004). CHSP60 antibodies were detected in 69.5% of women with tubal occlusion and 49.7% of women with other causes of infertility (<jats:italic>P<\/jats:italic>\u2003=\u20030.01). CHSP60 antibody detection was unrelated to maternal age, number of oocytes collected, or percentage of oocytes fertilized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Detection of IgG antibody to CHSP60 may indicate persistence of <jats:italic>C. trachomatis<\/jats:italic> in the upper genital tract with low implantation rates resulting from a chronic inflammatory reaction. Alternatively, as human hsp60 is expressed in early stage embryogenesis, a cross\u2010reacting antibody may induce destruction of the embryo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2007.00539.x","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T13:13:03Z","timestamp":1282137183000},"page":"85-89","source":"Crossref","is-referenced-by-count":31,"title":["ORIGINAL ARTICLE: Antibody to the <i>Chlamydia trachomatis<\/i> 60\u2003kDa Heat Shock Protein in Follicular Fluid and <i>In Vitro<\/i> Fertilization Outcome"],"prefix":"10.1111","volume":"59","author":[{"given":"Sharon","family":"Jakus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Neuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Dieterle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Marie","family":"Bongiovanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven S.","family":"Witkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,24]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Sexually transmitted diseases","author":"Holmes KK","year":"1999"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.02.014"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57781-4"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg471"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh710"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg347"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81435-5"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.5.925"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2003.09.014"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70084-2"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81489-6"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.3.699"},{"key":"e_1_2_5_14_2","first-page":"80","article-title":"Mannose Binding Lectin (MBL) gene polymorphism and in vitro fertilization outcome","author":"Spandorfer SD","year":"2003","journal-title":"Fertil Steril"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0897.2007.00539.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0897.2007.00539.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T01:05:59Z","timestamp":1696986359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0897.2007.00539.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["10.1111\/j.1600-0897.2007.00539.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0897.2007.00539.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}