{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:13:18Z","timestamp":1761487998944},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T00:00:00Z","timestamp":1203552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>A decrease in factor XII (FXII) activity has been observed in women with unexplained recurrent miscarriages. Because of the many similarities between recurrent <jats:italic>in vitro<\/jats:italic> fertilization\u2010embryo transfer (IVF\u2010ET) failure and early pregnancy loss patients, we investigated whether women with recurrent IVF\u2010ET failure had low FXII activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Blood from 110 patients with three or more IVF\u2010ET failures was tested for FXII activity, autoantibodies and other coagulation parameters. These patients were compared with 191 recurrent miscarriage patients, 87 controls. FXII activity was measured by an activated partial thromboplastin time (APTT) assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Factor XII activity of the IVF\u2010ET failure group (median 79.5, range 37\u2013150) was significantly lower than that of control group (median 109, range 35\u2013225, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001 by Mann\u2013Whitney test) or that of recurrent pregnancy loss (RPL)group (median 92, range 20\u2013205). The FXII activity of IVF\u2010ET failure patients was positively correlated with age, but not associated with the number of IVF\u2010ET failures, infertile duration, autoantibodies, or other coagulation parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Decreased FXII activity may causally relate to reproductive failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2007.00564.x","type":"journal-article","created":{"date-parts":[[2008,2,22]],"date-time":"2008-02-22T02:20:29Z","timestamp":1203646829000},"page":"316-322","source":"Crossref","is-referenced-by-count":8,"title":["ORIGINAL ARTICLE: Decreased Factor XII Activity is Associated with Recurrent IVF\u2010ET Failure"],"prefix":"10.1111","volume":"59","author":[{"given":"Hidehiko","family":"Matsubayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Sugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noa","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruyo","family":"Atsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun\u2010ichiro","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,2,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.10.3819"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013991828598"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1055\/s-0038-1642386","article-title":"The prevalence of moderate and severe FXII (Hageman factor) deficiency among the normal population: evaluation of the incidence of FXII deficiency among 300 healthy blood donors","volume":"71","author":"Halbmayer WM","year":"1994","journal-title":"Thromb Haemost"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1647467"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1614368"},{"key":"e_1_2_7_7_2","first-page":"43","article-title":"Factor XII (Hageman factor) deficiency: a risk factor for development of thromboembolism. 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