{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:27:09Z","timestamp":1787063229332,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T00:00:00Z","timestamp":1215648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>\n                    <jats:bold>Problem\u2002<\/jats:bold>\n                    Recurrent spontaneous abortion (RSA) is a common clinical problem with a complex etiology of genetic and non\u2010genetic causes, which remains to be fully determined. IGF\u20102 stimulates trophoblast invasion, proliferation and maturation of placenta, while H19 RNA suppresses growth. As genomic imprinting plays a critical role in the development of placenta and embryo, our aim was to evaluate the possible role of variations in IGF\u20102 and H19 imprinted genes as factors of predisposition for RSA.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method of study\u2002<\/jats:bold>\n                    A case\u2013control study was conducted to determine the association between IGF\u20102 and H19 gene polymorphisms and the susceptibility to RSA in 113 couples with RSA and 226 controls. PCR\/RFLP were performed to analyze IGF\u20102 ApaI and H19 HhaI polymorphisms.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    We found a statistically significant difference in the genotype frequency distribution of IGF\u20102 ApaI polymorphism between males from couples with RSA and healthy males (\u03c7\n                    <jats:sup>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sup>\n                    (2)\u2003=\u200345.12;\n                    <jats:italic>P<\/jats:italic>\n                    \u2003&lt;\u20030.0001). There were no differences in the genotype and allele distribution of H19 polymorphism frequencies, or for the IGF\u20102 ApaI polymorphism between female groups.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    The presence of IGF\u20102 ApaI polymorphism in partners of RSA women could affect IGF\u20102 level of expression in placenta and embryo and represent a risk factor for RSA susceptibility.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0897.2008.00601.x","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T03:33:08Z","timestamp":1215660788000},"page":"111-117","source":"Crossref","is-referenced-by-count":21,"title":["ORIGINAL ARTICLE: Genetic Predisposition to Idiopathic Recurrent Spontaneous Abortion: Contribution of Genetic Variations in IGF\u20102 and H19 Imprinted Genes"],"prefix":"10.1111","volume":"60","author":[{"given":"Sa\u0161a","family":"Ostoji\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Pereza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miljenko","family":"Kapovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borut","family":"Peterlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.5.463"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04207-3"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(91)90138-B"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.11.2868"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081540898"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/308548a0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90313-1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/311374a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65309-6"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000091506"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2003.00035.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0288"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0015-0282(16)57048-4","article-title":"The 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