{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T13:27:17Z","timestamp":1771680437159,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold>  <jats:sc>l<\/jats:sc>\u2010selectin ligand has displayed mediating adhesion at the maternal\u2013fetal interface. Therefore, we investigated the impact of <jats:sc>l<\/jats:sc>\u2010selectin ligand on establishing pregnancy in women undergoing <jats:italic>in vitro<\/jats:italic> fertilization and embryo transfer (IVF\u2010ET).<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> Endometrium between cycle days LH +6 to +9 was obtained from 56 Chinese women referred for IVF and tested for <jats:sc>l<\/jats:sc>\u2010selectin ligand by immunohistochemistry and Western blot. The standard gonadotropin\u2010releasing hormone agonist long protocol was used for ovarian stimulation.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>  <jats:sc>l<\/jats:sc>\u2010selectin ligand was localized in the endometrial gland and luminal epithelial cells. Western blot analysis of endometrium identified four bands and levels of component 1, 2 and 4 were significantly higher in the pregnancy group than in the non\u2010pregnancy group (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05). Clinical pregnancy and implantation rates were higher in patients with high level <jats:sc>l<\/jats:sc>\u2010selectin ligand compared with those with low level (53.6%<jats:italic>versus<\/jats:italic> 25.0%, and 27.1%<jats:italic>versus<\/jats:italic> 12.1%, respectively, <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The presence of higher level <jats:sc>l<\/jats:sc>\u2010selectin ligand was associated with a better pregnancy outcome.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2008.00604.x","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T07:33:08Z","timestamp":1215675188000},"page":"127-134","source":"Crossref","is-referenced-by-count":37,"title":["ORIGINAL ARTICLE: High Expression of <scp>l<\/scp>\u2010Selectin Ligand in Secretory Endometrium is Associated with Better Endometrial Receptivity and Facilitates Embryo Implantation in Human Being"],"prefix":"10.1111","volume":"60","author":[{"given":"Bo","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Zhong","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong\u2010Huan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Li","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He\u2010Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm011"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.25.15403"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61781-6"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3781hyp"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.63.1.1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.4049\/jimmunol.138.12.4313","article-title":"Leukocyte\u2010endothelial 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