{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:18:47Z","timestamp":1765545527153},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T00:00:00Z","timestamp":1218585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold> The interleukin\u20101 system has been implicated in pregnancy outcome. Fetal carriage of interleukin\u20101 receptor antagonist (IL\u20101Ra) specific alleles has been associated with adverse pregnancy outcomes including spontaneous abortion and pre\u2010term labor. This study was undertaken to compare the frequency of IL\u20101RN*2 alleles among both male and female partners of couples experiencing recurrent pregnancy loss with that of fertile control couples.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> Buccal swabs were obtained from 42 couples experiencing recurrent pregnancy loss and from 20 fertile control couples. DNA was extracted from the buccal swabs and analyzed for the presence of IL\u20101RN variable number tandem repeat.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> No significant differences were found when the frequency of IL\u20101RN*2 polymorphisms were compared between fertile control couples and couples experiencing recurrent pregnancy loss. Similar results were also obtained when comparing women or men respectively from each group.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> IL\u20101RN*2 allele is not a risk factor for recurrent pregnancy loss.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2008.00617.x","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T02:47:41Z","timestamp":1218682061000},"page":"224-228","source":"Crossref","is-referenced-by-count":9,"title":["ORIGINAL ARTICLE: Interleukin 1 Receptor Antagonist Gene Polymorphisms Are Not Risk Factors for Recurrent Pregnancy Loss: Evaluation of Couples"],"prefix":"10.1111","volume":"60","author":[{"given":"Seth","family":"Levrant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn B.","family":"Coulam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajasingam S.","family":"Jeyendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2.2.3277884"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1542\/peds.90.6.846","article-title":"Fever revisited","volume":"90","author":"Kluger MJ","year":"1992","journal-title":"Pediatrics"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90127-F"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.071"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(02)00044-X"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00630-6"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00770-1"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122407"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00217368"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1997.tb00193.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61004-8"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)01459-6"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.10.052"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00256.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1998.4520"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.12.1419"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb03793.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70338-0"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb05549.x"},{"key":"e_1_2_5_21_2","article-title":"Pregnancy reconceived: what keeps a mother\u2019s immune system from treating her baby as foreign tissue? 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