{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:11:20Z","timestamp":1792894280817,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T00:00:00Z","timestamp":1218585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold> The immunological equilibrium at the feto\u2010maternal interphase contributes towards late gestational diseases like growth restriction (IUGR) pre\u2010eclampsia (PE) and hemolysis, elevated liver enzymes, low platelets (HELLP)\u2010syndrome. The state of activation of decidual dendritic cells (DC) has emerged as one of the central players influencing this immunological equilibrium.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> Paraffin\u2010embedded tissue sections from 27 pregnancies were immunostained for DC markers DEC\u2010205, DC\u2010SIGN, DC\u2010LAMP and costained for DC\u2010SIGN\/CD56 and DC\u2010SIGN\/ vascular endothelial growth factor receptor (VEGFR) \u20101 and \u20102. We investigated placental tissue of IUGR fetuses and of patients who developed PE or HELLP\u2010syndrome as well as placental tissue derived from normal pregnancies.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> We found that expression of DEC\u2010205 and DC\u2010SIGN was significantly upregulated in HELLP placentas, whereas expression of DC\u2010LAMP was abrogated almost entirely. Costaining showed an interaction between DC\u2010SIGN<jats:sup>+<\/jats:sup> DC and natural killer cells as well as costaining of VEGFR\u20101 and \u20102 and DC\u2010SIGN. Pre\u2010eclamptic and IUGR placentas showed no significant change in any of the investigated markers compared to normal controls.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Our data suggest a participation of DC\u2010mediated immunological mechanisms in HELLP syndrome.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2008.00619.x","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T02:47:41Z","timestamp":1218682061000},"page":"238-245","source":"Crossref","is-referenced-by-count":39,"title":["ORIGINAL ARTICLE: Distribution and Maturity of Dendritic Cells in Diseases of Insufficient 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