{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:47:52Z","timestamp":1790898472596,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,11,6]],"date-time":"2008-11-06T00:00:00Z","timestamp":1225929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold> Successful mammalian pregnancy requires a delicate immunological balance at the feto\u2010maternal interface that allows the semi\u2010allogeneic fetus to grow, while protecting mother and child from environmental pathogens. As in other mucosal tissues, antigen\u2010recognition and \u2010handling by professional antigen\u2010presenting cells such as dendritic cells (DC) determine the course of the subsequent immune response. DC at the feto\u2010maternal interface help shape this immunological equilibrium. Endometrial tissue secretes high quantities of glycodelin A (GdA) during the so\u2010called fertile window (i.e. the time of implantation of the blastocyst).<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> We investigated the effect of GdA on monocyte\u2010derived DC (moDC) regarding surface marker expression, endopinocytotic activity, cytokine profile as well as lymphoproliferative activity.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Upon pretreatment with GdA and subsequent maturation with tumor necrosis factor\u2010\u03b1 and interleukin (IL)\u20101\u03b2, moDC displayed a reduced expression of costimulatory molecules, an unchanged major histocompatibility complex\u2010II expression and persistence of DC\u2010SIGN positive cells. GdA\u2010pretreated moDC had a higher endopinocytotic activity, an increased IL\u201010 production and a dose\u2010dependent reduction in lymphoproliferative activity. GdA incubation alone did not alter the immature phenotype.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Our results suggest a model in which the human endometrium secretes high quantities of GdA during implantation and thereby helps to shape the unique immunological interaction between mother and fetus via decidual DC.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2008.00647.x","type":"journal-article","created":{"date-parts":[[2008,11,6]],"date-time":"2008-11-06T06:40:39Z","timestamp":1225953639000},"page":"501-512","source":"Crossref","is-referenced-by-count":45,"title":["ORIGINAL ARTICLE: Glycodelin A Induces a Tolerogenic Phenotype in Monocyte\u2010Derived Dendritic Cells <i>In 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