{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:44:54Z","timestamp":1761662694928},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T00:00:00Z","timestamp":1228953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold> To investigate the immunological mechanism of low\u2010dose mifepristone acting as a contraceptive at the level of the endometrium.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> Endometrial explants were cultured <jats:italic>in vitro<\/jats:italic> with or without mifepristone treatment for 24\u2003hr. Some tissues were fixed and immunostained for CD56, while other tissues were dissociated and cells analysed by three colour flow cytometry for CD3, CD56 and CD16.<\/jats:p><jats:p><jats:bold>Results and conclusion\u2002<\/jats:bold> Results showed a significant increase in the number of CD56<jats:sup>+<\/jats:sup> natural killer (NK) cells and the percentages of CD3<jats:sup>\u2212<\/jats:sup>\u2003CD56<jats:sup>+<\/jats:sup>\u2003CD16<jats:sup>\u2212<\/jats:sup> NK cell subset in the tissue treated with mifepristone, while the percentage of CD3<jats:sup>\u2212<\/jats:sup>\u2003CD56<jats:sup>+<\/jats:sup>\u2003CD16<jats:sup>+<\/jats:sup> NK cell subset remained unaffected. It shows that low\u2010dose mifepristone increases the number of CD56<jats:sup>+<\/jats:sup> NK cells and the percentage of CD3<jats:sup>\u2212<\/jats:sup>\u2003CD56<jats:sup>+<\/jats:sup>\u2003CD16<jats:sup>\u2212<\/jats:sup> NK subset in receptive endometrium and provides new insights into the immunological mechanism of low\u2010dose mifepristone as an anti\u2010implantation contraceptive drug.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2008.00664.x","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T18:36:58Z","timestamp":1229020618000},"page":"68-74","source":"Crossref","is-referenced-by-count":10,"title":["ORIGINAL ARTICLE: Mifepristone as an Anti\u2010Implantation Contraceptive Drug: Roles in Regulation of Uterine Natural Killer Cells during Implantation Phase"],"prefix":"10.1111","volume":"61","author":[{"given":"Hong\u2010Xia","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu\u2010Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Ling","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031945"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.12.009"},{"key":"e_1_2_5_4_2","first-page":"882","article-title":"Progesterone receptor antagonists","volume":"7","author":"Spitz IM","year":"2006","journal-title":"Curr Opin Investig Drugs"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60942-X"},{"key":"e_1_2_5_6_2","first-page":"633","article-title":"The biology of human natural killer\u2010cell subsets, Trends","volume":"22","author":"Cooper MA","year":"2001","journal-title":"Immunology"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(2001010)31:10<3121::AID-IMMU3121>3.0.CO;2-4"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)30062-0"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.04.001"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gag060"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91774-5"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000010279"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1742-1241.2002.tb11212.x","article-title":"The potential of mifepristone (RU486) as a female contraceptive drug","volume":"56","author":"Sarkar NN","year":"2002","journal-title":"Int J Clin Pract"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri886"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.07.035"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.06.007"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.9.2386"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.11.2727"},{"key":"e_1_2_5_19_2","first-page":"625","article-title":"Expression of T\u2010lymphocytes and cytokines in the decidua of mifepristone with misoprostol for terminating early pregancy","volume":"36","author":"Lu S","year":"2001","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg022"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031945"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60575-5"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2008.00595.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/6.1.28"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod60.4.871"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0021"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.05.012"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/8.3.255"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0280196"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.5.813"},{"key":"e_1_2_5_31_2","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1093\/oxfordjournals.humrep.a137982","article-title":"Expression of perforin,granzyme A and TIA\u20101 by human uterine CD56+ NK cells implies they are activated and capable of effector functions","volume":"8","author":"King A","year":"1993","journal-title":"Hum Reprod"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030305"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507835102"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021174"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm035"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500140370"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005996.pub2"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)62012-3"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0897.2008.00664.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0897.2008.00664.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T08:45:27Z","timestamp":1697013927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0897.2008.00664.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,11]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1111\/j.1600-0897.2008.00664.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0897.2008.00664.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,11]]}}}