{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:35:27Z","timestamp":1791902127865,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T00:00:00Z","timestamp":1240358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold>  <jats:italic>Chlamydia trachomatis<\/jats:italic> causes sexually transmitted infection and reproductive dysfunction worldwide. Identifying a population of endocervical T\u2010cells to target in vaccine development is likely to enhance efficacy of a vaccine and reduce reproductive tract dysfunction.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> Endocervical samples were obtained from young women and flow cytometric analysis was used to identify lymphocytes that appeared in the genital tract in response to sexually transmitted bacterial infections caused by <jats:italic>C.\u00a0trachomatis.<\/jats:italic><\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Increased numbers of \u03b14\u03b27+CLA+ memory T\u2010cells, a unique T\u2010cell phenotype, were found in the endocervix of human female subjects infected with <jats:italic>C.\u00a0trachomatis<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> A unique population of memory T lymphocytes expressing both \u03b14\u03b27 and CLA gain access to reproductive tract tissues during a sexually transmitted infection with <jats:italic>C.\u00a0trachomatis<\/jats:italic> and should be considered in development of vaccines against sexually transmitted infections.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2009.00705.x","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T06:45:51Z","timestamp":1240382751000},"page":"446-452","source":"Crossref","is-referenced-by-count":21,"title":["ORIGINAL ARTICLE: The Combination of the Gastrointestinal Integrin (\u03b14\u03b27) and Selectin Ligand Enhances T\u2010Cell Migration to the Reproductive Tract During Infection with <i>Chlamydia trachomatis<\/i>"],"prefix":"10.1111","volume":"61","author":[{"given":"Kathleen 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