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This is a review of the various immunological causes of RFL and the outcome of different treatment protocols.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> Both auto\u2010 and alloimmune maternal immunological abnormalities have been proposed to account for foetal loss. Among the autoimmune factors, anti\u2010phospholipid antibodies (APAs) have been demonstrated to be the strongest risk factors for foetal loss, the prevalence of which is as high as 40% in women with RFL. Other autoimmune antibodies implicated in RFL are anti\u2010nuclear antibodies (ANAs), anti\u2010thyroid antibodies and anti\u2010endothelial cell antibodies. The alloimmune factors implicated in pregnancy loss of unknown aetiology include abnormal natural killer (NK) cell activity, alteration in T helper 1 (Th1) and T helper 2 (Th2) ratios, presence of alloimmune antibodies like anti\u2010paternal cytotoxic antibodies, anti\u2010idiotypic antibodies, mixed lymphocyte reaction blocking antibodies and abnormal expression of HLA\u2010G molecules. Management of patients with RFL is mainly based on immunomodulatory (prednisolone, intravenous immunoglobulins, plasma exchange, paternal lymphocyte therapy), anti\u2010aggregation (aspirin) or anti\u2010coagulation (unfractionated or low molecular weight heparin) agents.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Low\u2010molecular\u2010weight heparin with low\u2010dose aspirin has been found to be the most effective treatment for women with APAs and RFL. Differences in dosage, timing of treatment, inclusion criteria, outcome assessment parameters etc. are some of the factors which have resulted in discrepancies in various reports.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Identification of the immunological mechanisms involved in pregnancy loss and the action of different therapeutic reagents is important so that effective therapies can be designed and investigated.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2009.00714.x","type":"journal-article","created":{"date-parts":[[2009,6,10]],"date-time":"2009-06-10T03:49:20Z","timestamp":1244605760000},"page":"9-24","source":"Crossref","is-referenced-by-count":30,"title":["REVIEW ARTICLE: Anti\u2010phospholipid Antibodies and Other Immunological Causes of Recurrent Foetal Loss \u2013 A Review of Literature of Various Therapeutic 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