{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:40:54Z","timestamp":1770482454875,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T00:00:00Z","timestamp":1249948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold> Epidemiological data suggested that pandemic influenza increased the risks of spontaneous abortion and premature labor, while seasonal influenza also increased the risk of schizophrenia in adolescence. However, their pathogenesis is so far unknown.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> The first trimester trophoblast cell lines, namely, Swan71 and HTR8 cells were challenged with A\/Udorn\/72 influenza virus (H3N2). At indicated time points, cells were examined for expression of influenza proteins. Viral replication in culture media, apoptosis and the expression of human leukocyte antigen (HLA)\u2010G were also examined.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> Intracellular localization of viral proteins was observed. Twenty\u2010four hours after inoculation, virus was detected in culture media while most cells fell into apoptosis. During apoptosis, expression of HLA\u2010G was unchanged.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> We revealed replication of low pathogenic influenza virus in the first trimester trophoblast cell lines. Placental damages are likely to be induced by direct cytopathic effects of influenza virus and subsequent apoptosis rather than down regulation of HLA\u2010G expression and subsequent rejection by maternal immune system.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2009.00723.x","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T08:08:21Z","timestamp":1249978101000},"page":"139-146","source":"Crossref","is-referenced-by-count":21,"title":["ORIGINAL ARTICLE: H3N2 Influenza A Virus Replicates in Immortalized Human First Trimester Trophoblast Cell Lines and Induces Their Rapid Apoptosis"],"prefix":"10.1111","volume":"62","author":[{"given":"Quang 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