{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T06:50:24Z","timestamp":1759042224844},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,8,24]],"date-time":"2009-08-24T00:00:00Z","timestamp":1251072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p><jats:bold>Problem\u2002<\/jats:bold> Hemolysis, elevated liver enzymes, and low platelet count syndrome (HELLP syndrome) is a life\u2010threatening variant of severe pre\u2010eclampsia in pregnant women. The complement system may play a role in the pathogenesis of this condition. We sought to determine serum complement 3 (C3) levels and its regulatory protein complement factor H (FH) in the HELLP syndrome.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> Twenty\u2010two pre\u2010eclamptic patients with HELLP syndrome (mean age: 27.8\u2003\u00b1\u20036.2\u2003years), 21 pre\u2010eclamptic patients without HELLP syndrome (mean age: 27.5\u2003\u00b1\u20036.8\u2003years) and 24 normotensive, healthy pregnant women (mean age: 26.1\u2003\u00b1\u20034.4\u2003years) were included in this study. Serum concentrations of C3 and FH were measured in all participants.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Concentrations of C3 and FH did not differ significantly between the study groups. In patients with the HELLP syndrome, FH levels were positively associated with platelet count.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> These findings did not support a major role of complement activation in the HELLP syndrome. In patients with HELLP, lower levels of FH are correlated with a reduced platelet count.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2009.00731.x","type":"journal-article","created":{"date-parts":[[2009,8,24]],"date-time":"2009-08-24T05:58:01Z","timestamp":1251093481000},"page":"238-242","source":"Crossref","is-referenced-by-count":7,"title":["ORIGINAL ARTICLE: Human Serum Complement C3 and Factor H in the Syndrome of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count"],"prefix":"10.1111","volume":"62","author":[{"given":"Elif","family":"Ari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Gul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesim Ozen","family":"Alahdab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alla Eldeen","family":"Kedrah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beyza","family":"Macunluoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atakan","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakki","family":"Arikan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cetin","family":"Ozener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,9,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2004.06.008"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000126245.35811.2a"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07324.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00362.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-144691"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(97)00057-X"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.04.008"},{"key":"e_1_2_5_10_2","first-page":"698","article-title":"Enhanced anaphylatoxin and terminal C5b\u20109 complement complex formation in patients with the syndrome of hemolysis, elevated liver enzymes, and low platelet count","volume":"76","author":"Haeger M","year":"1990","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_11_2","first-page":"46","article-title":"Complement activation in relation to development of preeclampsia","volume":"78","author":"Haeger M","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_12_2","first-page":"254","article-title":"Precipitable C4\u2010poor immune complexes in HELLP syndrome and pre\u2010eclampsia","volume":"195","author":"Boenig G","year":"1991","journal-title":"Z Geburtshilfe Perinatol"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2006.07.002"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070664"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537100802238494"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0897.2009.00731.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0897.2009.00731.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:30:03Z","timestamp":1696980603000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0897.2009.00731.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,11]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1111\/j.1600-0897.2009.00731.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0897.2009.00731.x","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,11]]}}}