{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:15:13Z","timestamp":1776273313989,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T00:00:00Z","timestamp":1257984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p> <jats:italic>Listeria monocytogenes<\/jats:italic> (LM) preferentially colonizes the placenta and causes fetal loss and systemic disease during pregnancy. As systemic CD8<jats:sup>+<\/jats:sup> T\u2010cell memory is critical in controlling LM infection, we addressed the issue as to whether it is modulated during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Pregnant mice were infected with LM and their immune response was quantified relative to the non\u2010pregnant cohort using advanced immunological techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pregnant mice exhibited progressive and massive placental LM infection leading to fetal resorptions. In contrast, they harbored significantly lower bacteria in spleen and liver relative to non\u2010pregnant controls, and rapidly cleared systemic infection. Both pregnant and non\u2010pregnant mice exhibited similar activation of systemic innate immunity. Moreover, LM infection in pregnant and non\u2010pregnant hosts evoked strong antigen\u2010specific cytolytic CD8<jats:sup>+<\/jats:sup> T cells that produced IFN\u2010\u03b3. Consequently, LM infection initiated during pregnancy afforded long\u2010term protective memory to secondary infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal hosts generate a normal <jats:italic>Listeria<\/jats:italic>\u2010specific adaptive immunity in particular CD8<jats:sup>+<\/jats:sup> T\u2010cell memory response suggesting that systemic listeriosis during pregnancy may be an immunopathology associated with placental infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2009.00766.x","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T04:00:50Z","timestamp":1258084850000},"page":"54-65","source":"Crossref","is-referenced-by-count":10,"title":["ORIGINAL ARTICLE: Pregnancy Does not Deter the Development of a Potent Maternal Protective CD8<sup>+<\/sup> T\u2010Cell Acquired Immune Response Against <i>Listeria Monocytogenes<\/i> Despite Preferential Placental 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