{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T11:12:18Z","timestamp":1753355538364},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T00:00:00Z","timestamp":1263254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p> <jats:bold>Citation<\/jats:bold> Chen L\u2010J, Gao H, Zhou H, Zou L, Zou P. Contribution of interferon\u2010\u03b3 receptor 1 gene polymorphisms to pre\u2010eclampsia in China. Am J Reprod Immunol 2010; 63: 331\u2013338<\/jats:p><jats:p><jats:bold>Problem\u2002<\/jats:bold> As gene polymorphisms of cytokines receptors have been found to significantly influence cell responses to cytokines, the aim of this study was to test the hypothesis that IFN\u2010\u03b3 receptor 1 (IFNGR1) gene polymorphisms may contribute to the pathogenesis of pre\u2010eclampsia.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> One hundred and sixty\u2010four pre\u2010eclamptic patients (121 patients with mild pre\u2010eclampsia and 43 patients with severe pre\u2010eclampsia) and 171 controls were included. Polymorphisms of the IFNGR1 gene at positions \u2212611, \u2212270, +56 and +95 were genotyped with the matrix\u2010assisted laser desorption\/ionization time of flight mass spectrometry.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> This study showed a positive association between \u221256C\/C genotype (OR\u2003=\u20031.7; 95% CI\u2003=\u20031.1\u20132.7) and pre\u2010eclampsia. Although the genotype frequencies (except for \u221256C\/C) of the two polymorphisms were comparable between cases and controls, higher frequency of the \u2212611A\/\u221256C haplotype (OR\u2003=\u20031.450; 95% CI\u2003=\u20031.070\u20131.966) was noticed in patients versus controls. All patients and controls were homozygous for the \u2212270T\/T and +95T\/T genotypes. Specifically, the frequency of the \u221256C allele (OR\u2003=\u20031.838; 95% CI\u2003=\u20031.127\u20132.995) was higher among patients with severe pre\u2010eclampsia.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The IFNGR1 gene polymorphisms may contribute to the pathogenesis of pre\u2010eclampsia in our population.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2009.00801.x","type":"journal-article","created":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T02:42:33Z","timestamp":1263350553000},"page":"331-338","source":"Crossref","is-referenced-by-count":3,"title":["ORIGINAL ARTICLE: Contribution of Interferon\u2010\u03b3 Receptor 1 Gene Polymorphisms to Pre\u2010Eclampsia in China"],"prefix":"10.1111","volume":"63","author":[{"given":"Li\u2010Juan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441209"},{"key":"e_1_2_6_3_2","first-page":"26","article-title":"An epidemiological survey on obstetric emergency and relative complications in Guangdong 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