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Maternal plasma concentration of the pro\u2010inflammatory adipokine pre\u2010B\u2010cell\u2010enhancing factor (PBEF)\/visfatin is elevated in pregnant patients with acute pyelonephritis. Am J Reprod Immunol 2010; 63: 252\u2013262<\/jats:p><jats:p><jats:bold>Problem\u2002<\/jats:bold> Visfatin\/pre\u2010B\u2010cell\u2010enhancing factor (PBEF) has been implicated in the regulation of the innate immune system, as well as in glucose metabolism. Specifically, visfatin plays a requisite role in delayed neutrophil apoptosis in patients with sepsis. The aim of this study was to determine whether pyelonephritis during pregnancy is associated with changes in maternal plasma visfatin concentration in normal weight and overweight\/obese patients.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> This cross\u2010sectional study included the following groups: (1) normal pregnant women (<jats:italic>n<\/jats:italic>\u2003=\u2003200) and (2) pregnant women with pyelonephritis (<jats:italic>n<\/jats:italic>\u2003=\u200340). Maternal plasma visfatin concentrations were determined by ELISA. Non\u2010parametric statistics was used for analyses.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> (1) The median maternal plasma visfatin concentration was significantly higher in patients with pyelonephritis than in those with a normal pregnancy; (2) among overweight\/obese pregnant women, those with pyelonephritis had a significantly higher median plasma visfatin concentration than women with a normal pregnancy; and (3) pyelonephritis was independently associated with higher maternal plasma visfatin concentrations after adjustment for maternal age, pre\u2010gestational body mass index, smoking status, gestational age at sampling, and birthweight.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Acute pyelonephritis during pregnancy is associated with a high circulating maternal visfatin concentration. These findings suggest that visfatin\/PBEF may play a role in the regulation of the complex and dynamic crosstalk between inflammation and metabolism during pregnancy.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2009.00804.x","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T03:47:20Z","timestamp":1263959240000},"page":"252-262","source":"Crossref","is-referenced-by-count":13,"title":["ORIGINAL ARTICLE: Maternal Plasma Concentration of the Pro\u2010Inflammatory Adipokine Pre\u2010B\u2010Cell\u2010Enhancing Factor (PBEF)\/Visfatin Is Elevated In Pregnant Patients with Acute 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