{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:08:14Z","timestamp":1791198494913,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T00:00:00Z","timestamp":1267660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p> <jats:bold>Citation<\/jats:bold> Nakashima A, Ito M, Shima T, Bac ND, Hidaka T, Saito S. Accumulation of IL\u201017\u2010positive cells in decidua of inevitable abortion cases. Am J Reprod Immunol 2010<\/jats:p><jats:p><jats:bold>Problem\u2002<\/jats:bold> Th17 cells, a new subset of helper T cells, have been focused on as a producer pro\u2010inflammatory cytokines. It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL\u201017\u2010producing cells in human spontaneous abortion.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> IL\u201017 expression was analyzed in decidual tissues among normal pregnancy, missed abortion, and inevitable abortion cases by immunohistochemistry and flow cytometry.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> IL\u201017<jats:sup>+<\/jats:sup> cells were accumulated in decidua and were detected in decidual CD4<jats:sup>+<\/jats:sup> T cells and few decidual CD8<jats:sup>+<\/jats:sup> T cells in spontaneous abortion cases. The number of decidual IL\u201017<jats:sup>+<\/jats:sup> cells in inevitable abortion cases involving active genital bleeding was significantly higher than that in normal pregnancy cases (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05). On the other hand, there were no significant differences in the numbers of decidual IL\u201017<jats:sup>+<\/jats:sup> cells between missed abortion cases and normal pregnancy subjects. Furthermore, the number of IL\u201017<jats:sup>+<\/jats:sup> cells was positively correlated with the number of neutrophils in spontaneous abortion cases.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> IL\u201017<jats:sup>+<\/jats:sup> cells might be involved in the induction of inflammation in the late stage of abortion, but not in the early stage of abortion.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2010.00812.x","type":"journal-article","created":{"date-parts":[[2010,3,5]],"date-time":"2010-03-05T02:59:41Z","timestamp":1267757981000},"page":"4-11","source":"Crossref","is-referenced-by-count":122,"title":["Accumulation of IL\u201017\u2010Positive Cells in Decidua of Inevitable Abortion Cases"],"prefix":"10.1111","volume":"64","author":[{"given":"Akitoshi","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Shima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Duy","family":"Bac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Hidaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520480053039"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/2006"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.9.2439"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02100.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1254"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.566"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141557"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1037"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah044"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gal032"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1117"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00032904"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800165"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.09.005"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)80164-7"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2007.tb04008.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.10.007"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0749"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00771.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.01.016"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00366.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071169"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4137"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.082763jb"}],"container-title":["American 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