{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:34:47Z","timestamp":1779363287357,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T00:00:00Z","timestamp":1266364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p> <jats:bold>Citation<\/jats:bold> Ozornek H, Ergin E, Jeyendran RS, Ozay AT, Pillai D, Coulam C. Is Apolipoprotien E codon 112 polymorphisms associated with recurrent pregnancy loss? Am J Reprod Immunol 2010; 64: 87\u201392<\/jats:p><jats:p><jats:bold>Problem\u2002<\/jats:bold> To compare the prevalence of 112T&gt;C point mutations among women experiencing RPL with fertile control women.<\/jats:p><jats:p><jats:bold>Method of Study\u2002<\/jats:bold> Buccal swabs were obtained from 232 individuals: 136 with a history of \u22652 abortions, 37 with at least 2 live births and 59 with a history of deep vein thrombosis (DVT). DNA was extracted and PCR amplification of Apo E codons was performed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The allelic frequency of a cytosine at position 112 was 11.4% (31\/272) among patients experiencing RPL, compared with a frequency of 5.4% (4\/74) among the fertile controls (<jats:italic>P<\/jats:italic>\u2003=\u20030.19) and 19.5% (23\/118) among individuals with a history of DVT. However, significantly more E3\/E4 and E4\/E4 genotypes were seen among individuals experiencing RPL and DVT than fertile controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Apo E4 codon 112C point mutation is, by itself, not associated with an elevated risk of recurrent pregnancy loss, but rather codon 112C in association with codon 158C is a risk factor for RPL.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2010.00814.x","type":"journal-article","created":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T03:30:49Z","timestamp":1266463849000},"page":"87-92","source":"Crossref","is-referenced-by-count":14,"title":["Is Apolipoprotien E codon 112 Polymorphisms Associated with Recurrent Pregnancy Loss?"],"prefix":"10.1111","volume":"64","author":[{"given":"Hakan","family":"Ozornek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Ergin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajasingam S.","family":"Jeyendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev T.","family":"Ozay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delanie","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Coulam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3283935"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.6.487"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1016\/S0021-9258(18)34702-1","article-title":"Human apolipoprotein E: the complete amino acid sequence","volume":"257","author":"Rall SC","year":"1982","journal-title":"J Biol Chem"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0895-486"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2008.00659.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00376.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0720-048X(90)90162-5"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.1016\/S0021-9258(18)68779-4","article-title":"Human apolipoprotein E3 in aqueous solution. 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