{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:42:05Z","timestamp":1791895325771,"version":"4.3.4"},"reference-count":89,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T00:00:00Z","timestamp":1269820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p> <jats:bold>Citation<\/jats:bold> Koga K, Mor G. Toll\u2010like receptors at the maternal\u2013fetal interface in normal pregnancy and pregnancy disorders. Am J Reprod Immunol 2010<\/jats:p><jats:p>Toll\u2010like receptors (TLR) form the major family of pattern recognition receptors (PRR) that are involved in innate immunity. Innate immune responses against microorganisms at the maternal\u2013fetal interface may have a significant impact on the success of pregnancy, as intrauterine infections have been shown to be strongly associated with certain disorders of pregnancy. At the maternal\u2013fetal interface, TLRs are expressed not only in the immune cells but also in non\u2010immune cells such as trophoblasts and decidual cells; moreover, their expression patterns vary according to the stage of pregnancy. Here, we will describe potential functions of TLRs in these cells, their recognition and response to microorganisms, and their involvement in the innate immunity. The impact of TLR\u2010mediated innate immune response will be discussed via animal model studies, as well as clinical observations.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2010.00848.x","type":"journal-article","created":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T07:12:46Z","timestamp":1269846766000},"page":"587-600","source":"Crossref","is-referenced-by-count":253,"title":["REVIEW ARTICLE: Toll\u2010Like Receptors at the Maternal\u2013Fetal Interface in Normal Pregnancy and Pregnancy 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