{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:24:46Z","timestamp":1782959086577,"version":"3.54.5"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T00:00:00Z","timestamp":1296432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p> <jats:bold>Citation<\/jats:bold> \u2028Jin L\u2010P, Fan D\u2010X, Li D\u2010J. Regulation of costimulatory signal in maternal\u2010fetal immune tolerance. Am J Reprod Immunol 2011; 66: 76\u201383<\/jats:p><jats:p>A pregnancy is associated with modifications in the immune status of the mother, but the mechanisms are not well understood. Several observations have indicated that CD28\/CTLA\u20104 and B7\u20101\/B7\u20102 are involved in the maternal\u2013fetal immune regulation. This review aims to recapitulate our current knowledge concerning the role of CD28\/CTLA\u20104 and B7\u20101\/B7\u20102 in maternal\u2013fetal immune regulation.\u2003Several studies suggest that up\u2010regulation of B7\u20102 and\/or CD28 and\/or down\u2010regulation of CTLA\u20104 are correlated with the occurrence of pregnancy loss. Therefore, an accurate expression of costimulatory molecules at the maternal\u2013fetal interface may ensure that the decidual cells do not elicit a \u2018danger\u2019 signal to the maternal immune system, perhaps instead contributing to the establishment of immune tolerance <jats:italic>in vivo<\/jats:italic>. It is showed that costimulation blockade with anti\u2010B7 mAbs results in altered allogeneic T\u2010cell response and overcomes increased maternal rejection to the fetus, which improves fetus growth in the abortion\u2010prone system. These findings suggest that the anti\u2010B7\u2010treated T cells not only function as potent suppresser cells but also exert immunoregulatory effect on the maternal T cells. This procedure might be potentially useful to immunotherapy for human recurrent spontaneous abortion.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2010.00982.x","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T09:27:13Z","timestamp":1296466033000},"page":"76-83","source":"Crossref","is-referenced-by-count":16,"title":["Regulation of Costimulatory Signal in Maternal\u2013Fetal Immune 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