{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:04:06Z","timestamp":1775275446818,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,1,24]],"date-time":"2011-01-24T00:00:00Z","timestamp":1295827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p> <jats:bold>Citation<\/jats:bold> \u2028Torricelli M, Bellisai F, Novembri R, Galeazzi LR, Iuliano A, Voltolini C, Spreafico A, Galeazzi M, Petraglia F. High levels of maternal serum IL\u201017 and activin A in pregnant women affected by systemic lupus erythematosus. Am J Reprod Immunol 2011; 66: 84\u201389<\/jats:p><jats:p><jats:bold>Problem\u2002<\/jats:bold> To evaluate changes of serum IL\u201017, activin A, follistatin, and other cytokines during pregnancy in women with systemic lupus erythematosus (SLE).<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> A group of patients with SLE and controls were longitudinally studied, collecting a blood sample before and during three trimesters of pregnancy. Serum activin A, follistatin, IL\u201017, IL\u20106, IL\u201010, and TNF\u2010\u03b1 concentrations were evaluated by specific ELISA.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Before pregnancy, while serum IL\u201017, IL\u20106, IL\u201010, and TNF\u2010\u03b1 resulted significantly higher in women with SLE (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001), activin A and follistatin were not changed. Serum IL\u201017 concentrations were higher in SLE than in controls with no changes during pregnancy. IL\u20106 increased in both groups, resulting higher in SLE than in controls only in the first trimester (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). IL\u201010 concentration in SLE increased during pregnancy resulting significantly higher than in controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). TNF\u2010\u03b1 levels were higher in SLE than in controls in third trimester (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). Serum activin A levels in SLE were significantly higher than in controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) at third trimester.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Women with SLE show increased secretions of activin A, IL\u201017, IL\u20106, IL\u201010, and TNF\u2010\u03b1 during gestation, with a different trend for the various cytokines. These data suggest that patients with SLE have a hyper\u2010reactive immune system, probably receiving a placental contribution.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2011.00978.x","type":"journal-article","created":{"date-parts":[[2011,1,25]],"date-time":"2011-01-25T01:48:26Z","timestamp":1295920106000},"page":"84-89","source":"Crossref","is-referenced-by-count":27,"title":["High Levels of Maternal Serum IL\u201017 and Activin A in Pregnant Women Affected by Systemic Lupus Erythematosus"],"prefix":"10.1111","volume":"66","author":[{"given":"Michela","family":"Torricelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Bellisai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Novembri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luna 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