{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:58:36Z","timestamp":1763017116366},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,20]],"date-time":"2011-06-20T00:00:00Z","timestamp":1308528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:bold>Citation<\/jats:bold> Szereday L, Miko E, Meggyes M, Barakonyi A, Farkas B, Varnagy A, Bodis J, Lynch L, O\u2019Farrelly C, Szekeres\u2010Bartho J. Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy. Am J Reprod Immunol 2012; 67: 9\u201316<\/jats:p><jats:p><jats:bold>Problem\u2002<\/jats:bold> The aim of this study was to investigate the phenotype and commitment of decidual haematopoietic progenitor cells (HPCs) in healthy pregnant women and in women with early miscarriage.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> Peripheral blood and decidual tissue from healthy and pathological pregnant women were examined for HPCs and lymphoid progenitors using flow cytometric analysis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Compared with peripheral blood, we found a significant increase in decidual HPCs in both healthy pregnant women and women with spontaneous abortion. T\/NK, natural killer (NK), gamma\u2010delta and NKT cell progenitors were identified in all peripheral blood and decidual samples. In pathologic pregnant women, the ratios of decidual T\/NK and NK cell progenitors were significantly increased compared with healthy pregnant controls.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> We demonstrated decidual cells with haematopoietic progenitor cell phenotype in human decidua. Increased levels of NK progenitors in the decidua of women with early spontaneous abortion suggest a dysregulation of this pathway that may contribute to pregnancy failure.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2011.01029.x","type":"journal-article","created":{"date-parts":[[2011,6,20]],"date-time":"2011-06-20T09:43:20Z","timestamp":1308563000000},"page":"9-16","source":"Crossref","is-referenced-by-count":16,"title":["Commitment of Decidual Haematopoietic Progenitor Cells in First Trimester Pregnancy"],"prefix":"10.1111","volume":"67","author":[{"given":"Laszlo","family":"Szereday","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Miko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matyas","family":"Meggyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliz","family":"Barakonyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balint","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akos","family":"Varnagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozsef","family":"Bodis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cliona","family":"O\u2019Farrelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Szekeres\u2010Bartho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.5.480"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.149.6.2203"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162491699"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.082763jb"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/10.suppl_2.14"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00287.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh783"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01199.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod58.4.995"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.4049\/jimmunol.153.11.4934","article-title":"Expression of recombinase\u2010activating genes (RAG\u20101 and 2) in human decidual mononuclear cells","volume":"153","author":"Hayakawa S","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1995.1046"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.4049\/jimmunol.159.7.3266","article-title":"Gamma delta T cells of human early pregnancy decidua: evidence for local proliferation, phenotypic heterogeneity, and extrathymic differentiation","volume":"159","author":"Mincheva\u2010Nilsson L","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del456"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611098104"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1845"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-106294"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.4049\/jimmunol.159.12.5931","article-title":"Role of IL\u201015\/IL\u201015 receptor \u03b2\u2010chain in natural killer 1.1+ T cell receptor\u2010\u03b3\u03b4 cell development","volume":"159","author":"Ohteki TS","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.4049\/jimmunol.161.2.707","article-title":"The role of IL\u20107 in thymic and extrathymic development of TCR\u03b3\u03b4 cells","volume":"161","author":"Laky K","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1995.tb00908.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052507"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.4049\/jimmunol.156.10.4027","article-title":"Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. 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