{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:06:34Z","timestamp":1793156794007,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T00:00:00Z","timestamp":1309737600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:sec><jats:label\/><jats:p> <jats:bold>Citation<\/jats:bold> Nevers T, Kalkunte S, Sharma S. Uterine Regulatory T Cells, IL\u201010 and hypertension. Am J Reprod Immunol 2011; 66 (Suppl. 1): 88\u201392<\/jats:p><\/jats:sec><jats:sec><jats:title>Problem<\/jats:title><jats:p>Regulatory T cells (T<jats:sub>reg<\/jats:sub>) are a vital immune cellular population at the maternal\u2013fetal interface. They are likely to aid in immune tolerance by dampening the harmful effects of other immune cellular populations through cell\u2013cell\u2010mediated interactions as well as by producing IL\u201010 and TGF\u2010\u03b2. In addition to the anti\u2010inflammatory properties, IL\u201010 has emerged as an important vascular cytokine choreographing endovascular interactions and angiogenesis and regulates hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Review of innovative concepts to understand the temporal role of T<jats:sub>regs<\/jats:sub> in both mouse and human pregnancy, particularly whether uterine T<jats:sub>reg<\/jats:sub> play a potential role in regulating vascular homeostasis and blood flow during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T<jats:sub>reg<\/jats:sub> guard immune tolerance, getting cytotoxically activated under certain conditions, leading to adverse pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite increasing evidence of T<jats:sub>reg<\/jats:sub> tissue\u2010specific expansion and functional plasticity, their role in vascular activity, pre\u2010eclampsia or gestational diabetes is obscure and needs closer investigation to delineate its role later during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2011.01040.x","type":"journal-article","created":{"date-parts":[[2011,7,4]],"date-time":"2011-07-04T17:44:17Z","timestamp":1309801457000},"page":"88-92","source":"Crossref","is-referenced-by-count":48,"title":["Uterine Regulatory T cells, IL\u201010 and 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