{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:08:33Z","timestamp":1767888513391,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:00:00Z","timestamp":1322784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Citation<\/jats:bold> Zenclussen ML, Jensen F, Rebelo S, El\u2010Mousleh T, Casalis PA, Zenclussen AC. Heme oxygenase\u20101 expression in the ovary dictates a proper oocyte ovulation, fertilization, and corpora lutea maintenance. Am J Reprod Immunol 2012; 67: 376\u2013382<\/jats:p><jats:p><jats:bold>Problem\u2002<\/jats:bold> Animals deficient in Heme oxygenase\u20101 (HO\u20101, <jats:italic>Hmox1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice) have impaired pregnancies, characterized by intrauterine fetal death. HO\u20101 expression has been shown to be essential for pregnancy by dictating placentation and intrauterine fetal development. Its absence leads to intrauterine fetal growth restriction and fetal loss, which is independent of the immune system. Defect in previous steps, e.g., ovulation, may, however, also count for their poor reproductive outcome.<\/jats:p><jats:p><jats:bold>Method of study\u2002<\/jats:bold> Here, we investigated ovulation after hormonal hyperstimulation in <jats:italic>Hmox1<\/jats:italic> wild\u2010type and knockout animals.<\/jats:p><jats:p><jats:bold>Results and Conclusions\u2002<\/jats:bold> We observed that animals lacking HO\u20101 produced significantly less oocytes after hormonal stimulation than wild type animals and this was mirrored by the number of corpora lutea in the ovary. Furthermore, ovulated oocytes from <jats:italic>Hmox1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> animals were poorly fertilized compared with those from wild\u2010type animals. In conclusion, we demonstrate here that HO\u20101 plays a pivotal role in the process of oocyte ovulation as well as fertilization, bringing to light a new and unsuspected role for HO\u20101.<\/jats:p>","DOI":"10.1111\/j.1600-0897.2011.01096.x","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T12:17:47Z","timestamp":1322914667000},"page":"376-382","source":"Crossref","is-referenced-by-count":24,"title":["Heme Oxygenase\u20101 Expression in the Ovary Dictates a Proper Oocyte Ovulation, Fertilization, and Corpora Lutea Maintenance"],"prefix":"10.1111","volume":"67","author":[{"given":"Maria 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