{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T07:32:40Z","timestamp":1700551960457},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>a2 isoform of vacuolar <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content>ase (<jats:styled-content style=\"fixed-case\"><jats:roman>Atp6v0a2<\/jats:roman><\/jats:styled-content>) is important for maintaining the delicate immunological balance required for successful pregnancy. The objective of this investigation is to study the dynamic changes in spleen and blood that appear during spontaneous abortion in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:roman>Atp6v0a2<\/jats:roman><\/jats:styled-content> was measured in multiple immune cell populations from spleen and blood recovered from non\u2013abortion\u2010prone and abortion\u2010prone mating combinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:roman>Atp6v0a2<\/jats:roman><\/jats:styled-content> expression was significantly lower (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a00.01) in the spleen recovered from abortion\u2010prone \u2640<jats:styled-content style=\"fixed-case\">CBA<\/jats:styled-content>\u00a0\u00d7\u00a0\u2642<jats:styled-content style=\"fixed-case\">DBA<\/jats:styled-content> mating on days 12 and 16 of pregnancy when compared to non\u2013abortion\u2010prone \u2640<jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">c<\/jats:styled-content>\u00a0\u00d7\u00a0\u2642<jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c and \u2640<jats:styled-content style=\"fixed-case\">CBA<\/jats:styled-content>\u00a0\u00d7\u00a0\u2642<jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c matings. Flow cytometric studies showed that significantly decreased expression of <jats:styled-content style=\"fixed-case\"><jats:roman>Atp6v0a2<\/jats:roman><\/jats:styled-content> in splenic <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup>, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>14<jats:sup>+<\/jats:sup> cells directly correlated with the high percentages of fetal resorption observed in abortion\u2010prone mating on days 12 and 16 of pregnancy. In blood, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup>, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup>, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19<jats:sup>+<\/jats:sup> cells had a significantly reduced expression of <jats:styled-content style=\"fixed-case\"><jats:roman>Atp6v0a2<\/jats:roman><\/jats:styled-content> in abortion\u2010prone mating compared to the non\u2013abortion\u2010prone mating combinations only on day 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This deceased expression of <jats:styled-content style=\"fixed-case\"><jats:roman>Atp6v0a2<\/jats:roman><\/jats:styled-content> in the various immune cell populations of the spleen and blood suggests that the maternal environment is not supportive to fetus and leads to poor pregnancy outcome in the abortion\u2010prone mating model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2011.01098.x","type":"journal-article","created":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T14:06:55Z","timestamp":1325858815000},"page":"421-433","source":"Crossref","is-referenced-by-count":8,"title":["Abortion\u2010Prone Mating Influences Alteration of Systemic a2 Vacuolar <scp>ATP<\/scp>ase Expression in Spleen and Blood Immune Cells"],"prefix":"10.1111","volume":"67","author":[{"given":"Mukesh K.","family":"Jaiswal","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Rosalind Franklin University of Medicine and Science North Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M.","family":"Mallers","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Rosalind Franklin University of Medicine and Science North Chicago IL 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