{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:02:24Z","timestamp":1793674944732,"version":"4.5.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Soluble triggering receptor expressed on myeloid cells\u20101 (<jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101) is a useful biomarker of infection and inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>We studied serum and follicular fluid <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 in infertile patients (<jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content><\/jats:italic>\u00a0=\u00a0110) utilizing enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum and follicular <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 were in good correlation (Pearson's correlation 0.56, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.0001) with higher values in follicular fluid (140.4\u00a0\u00b1\u00a034.4 and 115.6\u00a0\u00b1\u00a035.1\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>,<jats:italic> t<\/jats:italic>\u2010test, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00.0001). Endometriosis associated with lower follicular and serum <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 compared with male factor infertility patients (age\u2010adjusted <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u221225.7\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>,<jats:italic> <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.018; <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u221222.1\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>,<jats:italic> <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.030). No associations between follicular or serum <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 and clinical parameters were found, except higher serum <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 associated with lower embryo quality in all patients (adjusted <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.3%, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.033), with a cutoff value between 111.5 and 113.3\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> (OR\u00a0=\u00a00.38, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.048; OR\u00a0=\u00a00.34, <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00.028) predicting that more than 39% of embryos would be with good quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">sTREM<\/jats:styled-content>\u20101 could represent a prognostic marker for female fecundity, probably indicating impaired inflammatory reaction of immune system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2011.01102.x","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T02:58:15Z","timestamp":1326164295000},"page":"68-74","source":"Crossref","is-referenced-by-count":4,"title":["Serum <scp>sTREM<\/scp>\u20101 (Soluble Triggering Receptor Expressed on Myeloid Cells\u20101) Associates Negatively with Embryo Quality in Infertility Patients"],"prefix":"10.1111","volume":"68","author":[{"given":"Kadri","family":"Haller\u2010Kikkatalo","sequence":"first","affiliation":[{"name":"Immunology Group Institute of General and Molecular Pathology, University of Tartu Tartu Estonia"},{"name":"Competence Centre on Reproductive 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