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Plasminogen activator inhibitor type 1 plays a significant role during the early phases of placental vascular remodelling and regulates the trophoblast invasion through controlling plasmin activity. Endometrial cell surface protein integrin alphaV\/beta3, responsible for the adhesion of the embryo, has had also the same subunit beta3, which is component of integrin alpha<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>b\/beta3 connected with platelet aggregability. Prothrombin, furthermore, has had a debatable effect upon endothelial and mesenchymal cells and possible contribution on embryo vascular development. Confoundable data have been present about the role of coagulation factor <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> and its role for implantation. These and other coagulation factors have relatively common gene polymorphisms that enhanced their activity. This review discusses the effect of increased coagulation activity on implantation process, which is not yet fully determined. 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