{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:12:55Z","timestamp":1768871575991,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T00:00:00Z","timestamp":1341964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The aim of this study was to evaluate serum procalcitonin (PCT), C\u2010reactive protein (CRP), and plasma D\u2010Dimer levels in mild and severe pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Serum PCT, CRP, and D\u2010Dimer levels were analyzed in 64 cases with pre\u2010eclampsia as the study group and 33 healthy pregnant women in the third trimester as the control group. Pre\u2010eclamptic group consisted of mild (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) and severe pre\u2010eclamptic subgroup (<jats:italic>n\u00a0<\/jats:italic>=\u00a033). Laboratory results were compared between the groups and diagnostic usefulness of these parameters were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PCT, CRP, and D\u2010Dimer levels were significantly higher in study group than the control group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001). PCT, CRP, and D\u2010Dimer were significantly higher in the patients with severe pre\u2010eclampsia than mild pre\u2010eclampsia. There were significant positive correlations between these markers and mean arterial pressure (MAP). Logistic regression analysis using the control and pre\u2010eclampsia group showed that higher PCT (OR, 15.68; 95%\u2010CI, 3.15\u201378.10), CRP (OR, 14.29; 95%\u2010CI, 3.08\u201366.34), and D\u2010Dimer levels (OR, 4.97; 95%\u2010CI, 1.22\u201320.29) were found to be risk factors significantly associated with pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study results confirm that evidence of a possible exaggerated systemic inflammatory response in pre\u2010eclampsia especially in severe pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2012.01171.x","type":"journal-article","created":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T13:05:14Z","timestamp":1342011914000},"page":"331-337","source":"Crossref","is-referenced-by-count":33,"title":["An Analysis of <scp>C<\/scp>\u2010Reactive Protein, Procalcitonin, and <scp>D<\/scp>\u2010Dimer in Pre\u2010Eclamptic 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