{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:03:23Z","timestamp":1759341803652},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"Problem<\/jats:title>Women with a history of recurrent pregnancy losses (RPL<\/jats:styled-content>) and unexplained infertility (UI<\/jats:styled-content>) have a high incidence of preeclampsia (PE<\/jats:styled-content>) and other obstetrical complications. We aimed to investigate the incidence of PE<\/jats:styled-content> and other obstetrical complications in women with RPL<\/jats:styled-content> or UI<\/jats:styled-content> who were treated with anti\u2010inflammatory and anticoagulant treatment.<\/jats:p><\/jats:sec>Methods<\/jats:title>The medical records of 72 women who delivered a live born infant from January 2008 to December 2009 with anti\u2010inflammatory (prednisone and\/or intravenous immunoglobulin G) and anticoagulant (low\u2010molecular\u2010weight heparin and low\u2010dose aspirin) treatment were reviewed retrospectively. A total of 41 women with a history of RPL<\/jats:styled-content> and 31 with UI<\/jats:styled-content> were enrolled as a study group.<\/jats:p><\/jats:sec>Results<\/jats:title>All patients had at least one or more positive test results for autoantibodies, thrombophilic gene mutations, elevated proportion of peripheral blood CD<\/jats:styled-content>56+<\/jats:sup> NK<\/jats:styled-content> cells or NK<\/jats:styled-content> cell cytotoxicities, or high T helper 1 to T helper 2 cytokine\u2010producing CD<\/jats:styled-content>3+<\/jats:sup>\/CD<\/jats:styled-content>4+<\/jats:sup>cell ratios. The incidence of PE<\/jats:styled-content> was 5.6% (n\u00a0=<\/jats:italic>\u00a04), which was comparable to that of general population (2009 CDC<\/jats:styled-content> data) (P\u00a0<\/jats:italic>>\u00a00.05); one of them developed HELLP<\/jats:styled-content> syndrome and none exacerbated to eclampsia. Preterm birth was more frequent in study group than general population (21.7 versus 10.4%, P\u00a0<\/jats:italic><\u00a00.028); however, early preterm birth (<34\u00a0weeks of gestation, 1.72%), small or large for gestation (SGA<\/jats:styled-content> or LGA<\/jats:styled-content>) (10.6 and 4.3%, each), gestational diabetes (GDM<\/jats:styled-content>) (4.2%), and abruptio placentae (0 of 72) were not increased in study group as compared to general population data.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The incidences of PE<\/jats:styled-content>, GDM<\/jats:styled-content>, SGA<\/jats:styled-content>, LGA<\/jats:styled-content>, early preterm birth, and abruptio placentae are not increased in women with RPL<\/jats:styled-content> or UI<\/jats:styled-content> who were administered anti\u2010inflammatory and anticoagulation treatment compared to general population. The potential role of anti\u2010inflammatory and anticoagulation treatment in prevention of obstetrical complications in women with immune abnormalities and thrombophilia is suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0897.2012.01178.x","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T15:18:28Z","timestamp":1343402308000},"page":"418-427","source":"Crossref","is-referenced-by-count":27,"title":["Obstetrical Outcome of Anti\u2010Inflammatory and Anticoagulation Therapy in Women with Recurrent Pregnancy Loss or Unexplained Infertility"],"prefix":"10.1111","volume":"68","author":[{"given":"Ae Ra","family":"Han","sequence":"first","affiliation":[{"name":"Reproductive Medicine Program Department of Obstetrics and Gynecology The Chicago Medical School at Rosalind Franklin University of Medicine and Science Vernon Hills IL 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