{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:50:16Z","timestamp":1793994616872,"version":"4.8.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":6769,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1111\/j.1600-6143.2004.00428.x","type":"journal-article","created":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T11:03:34Z","timestamp":1084532614000},"page":"946-952","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"title":["Increased Risk of Thrombotic Microangiopathy in Patients Receiving a Cyclosporin\u2013Sirolimus Combination"],"prefix":"10.1016","volume":"4","author":[{"given":"Marie-Chantal","family":"Fortin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Andr\u00e9","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Madore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo-Ann","family":"Fug\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"P\u00e2quet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"St-Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9e","family":"H\u00e9bert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1600-6143.2004.00428.x_bib1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1046\/j.1523-1755.2002.00543.x","article-title":"Post-transplant hemolytic\u2013uremic syndrome","volume":"62","author":"Ruggenenti","year":"2002","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib2","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1681\/ASN.V641160","article-title":"Recurrent hemolytic uremic syndrome in an adult renal allograft recipient. current concepts and management","volume":"6","author":"Agarwal","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib3","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1046\/j.1523-1755.2001.060003831.x","article-title":"Thrombotic microangiopathy, hemolytic uremic syndrome and thrombotic thrombocytopenic purpura","volume":"60","author":"Ruggenenti","year":"2001","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ki.1995.261","article-title":"The hemolytic uremic syndrome","volume":"47","author":"Remuzzi","year":"1995","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0889-8588(18)30514-8","article-title":"Thrombotic thrombocytopenic purpura and related disorders","volume":"4","author":"Ruggenenti","year":"1990","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ki.1987.206","article-title":"HUS and TTP. variable expression of a single entity","volume":"32","author":"Remuzzi","year":"1987","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib7","first-page":"81","article-title":"Thrombotic thrombocytopenic purpura and the hemolytic syndrome","volume":"34","author":"Kwaan","year":"1997","journal-title":"Semin Hematol"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib8","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1182\/blood.V93.11.3831","article-title":"Endothelial cells undergoing apoptosis become proadhesive for nonactivated platelets","volume":"93","author":"Bombeli","year":"1999","journal-title":"Blood"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib9","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1182\/blood.V89.7.2429","article-title":"Apoptotic vascular endothelial cells become procoagulant","volume":"89","author":"Bombeli","year":"1997","journal-title":"Blood"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib10","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1182\/blood.V89.4.1121","article-title":"Pathophysiologic implications of membrane phospholipid asymmetry in blood cells","volume":"89","author":"Zwaal","year":"1997","journal-title":"Blood"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib11","first-page":"281","article-title":"Apoptosis is associated with increased cell surface tissue factor procoagulant activity","volume":"75","author":"Greeno","year":"1996","journal-title":"Lab Invest"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib12","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1046\/j.1523-1755.2001.00935.x","article-title":"Vascular endothelial growth factor (VEGF121) protects rats from renal infarction in thrombotic microangiopathy","volume":"60","author":"Suga","year":"2001","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib13","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1046\/j.1523-1755.2000.00422.x","article-title":"Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy","volume":"58","author":"Kim","year":"2000","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1046\/j.1523-1755.1999.00299.x","article-title":"The Banff 97 working classification of renal allograft pathology","volume":"55","author":"Racusen","year":"1999","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib15","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1096\/fj.02-0500fje","article-title":"Blockade of the apoptotic machinery by cyclosporin A redirects cell death towards necrosis in arterial endothelial cells: regulation by reactive oxygen species and cathepsin D","volume":"17","author":"Raymond","year":"2003","journal-title":"FASEB J"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/bbrc.2002.6449","article-title":"Paracrine repercussions of preconditioning on angiogenesis and apoptosis of endothelial cells","volume":"291","author":"Raymond","year":"2002","journal-title":"Biochem Biophys Res Com"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib17","first-page":"523","article-title":"Apoptosis of endothelial cells is associated with paracrine induction of adhesion molecules: evidence for an IL-1B dependent paracrine loop","volume":"152","author":"H\u00e9bert","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib18","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.4049\/jimmunol.157.7.3105","article-title":"Sequential morphological events during apoptosis of human neutrophils","volume":"157","author":"H\u00e9bert","year":"1996","journal-title":"J Immunol"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib19","first-page":"1465","article-title":"In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note","volume":"21","author":"Grasl-Kraupp","year":"1995","journal-title":"Hepatology"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMra011295","article-title":"Strategies to improve long-term outcomes after renal transplantation","volume":"346","author":"Pascual","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib21","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1034\/j.1600-6143.2003.00018.x","article-title":"Sirolimus may promote thrombotic microangiopathy","volume":"3","author":"Saikali","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1034\/j.1600-6143.2003.00051.x","article-title":"Thrombotic micro-angiopathy with sirolimus-based immunosuppression. Potentiation of calcineurin-inhibitor-induced endothelial damage","volume":"3","author":"Robson","year":"2003","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0272-6386(03)00424-4","article-title":"Sirolimus-induced thrombotic microangiopathy in a renal transplant recipient","volume":"42","author":"Barone","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib24","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1097\/00007890-200112270-00010","article-title":"Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease","volume":"72","author":"Benito","year":"2001","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib25","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/00007890-200203150-00017","article-title":"De novo hemolytic uremic syndrome after kidney transplantation in patients treated with cyclosporine-sirolimus combination","volume":"73","author":"Langer","year":"2002","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000179580","article-title":"Le syndrome h\u00e9molytique ur\u00e9mique de l'enfant","volume":"4","author":"Habib","year":"1967","journal-title":"Nephron"},{"key":"10.1111\/j.1600-6143.2004.00428.x_bib27","first-page":"391","article-title":"Etude anatomo-pathologique de 35 observations de syndrome h\u00e9moytique et ur\u00e9mique de l'enfant","volume":"26","author":"Habib","year":"1969","journal-title":"Arch Fr Pediatr"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-6143.2004.00428.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522075384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522075384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-6143.2004.00428.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:30:09Z","timestamp":1761625809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522075384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S1600613522075384"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-6143.2004.00428.x","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2004,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Risk of Thrombotic Microangiopathy in Patients Receiving a Cyclosporin\u2013Sirolimus Combination","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1600-6143.2004.00428.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Journal of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}