{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:10:47Z","timestamp":1770502247429,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":5967,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1111\/j.1600-6143.2006.01414.x","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T04:02:34Z","timestamp":1150689754000},"page":"1820-1828","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Minimization of Immunosuppressive Therapy After Islet Transplantation: Combined Action of Heme Oxygenase-1 and PEGylation to Islet"],"prefix":"10.1016","volume":"6","author":[{"given":"D.Y.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Byun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/j.1600-6143.2006.01414.x_bib1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/00007890-198604000-00003","article-title":"Prolonged reversal of diabetes in the rat by transplantation of allogeneic islets from a single donor and cyclosporine treatment.","volume":"41","author":"Dibelius","year":"1986","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type I diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.","volume":"343","author":"Shapiro","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib3","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2337\/diabetes.50.4.710","article-title":"Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol.","volume":"50","author":"Ryan","year":"2001","journal-title":"Diabetes"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib4","doi-asserted-by":"crossref","first-page":"638","DOI":"10.2337\/diabetes.51.3.638","article-title":"Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice.","volume":"51","author":"Rabinovitch","year":"2002","journal-title":"Diabetes"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s00125-001-0745-x","article-title":"Combination therapy with low dose sirolimus and tacrolimus is synergistic in preventing spontaneous and recurrent autoimmune diabetes in non-obese diabetic mice.","volume":"45","author":"Shapiro","year":"2002","journal-title":"Diabetologia"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib6","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMra011295","article-title":"Strategies to improve long-term outcomes after renal transplantation.","volume":"346","author":"Pascual","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib7","unstructured":"EBPG Expert Group on Renal Transplantation. European best practice guidelines for renal transplantation. Nephrol Diabl Transplant 2002; 17(Suppl 4): 1\u201368."},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib8","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0140-6736(94)92070-2","article-title":"Peripheral neurotoxicity with tacrolimus.","volume":"343","author":"Ayres","year":"1994","journal-title":"Lancet"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib9","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/nbt0996-1107","article-title":"Encapsulated cell technology.","volume":"14","author":"Lanza","year":"1996","journal-title":"Nat Biotechnol"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00125-001-0729-x","article-title":"Considerations for successful transplantation of encapsulated pancreatic islets.","volume":"45","author":"De Vos","year":"2002","journal-title":"Diabetologia"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nm0103-104","article-title":"Cell encapsulation: Promise and progress.","volume":"9","author":"Orive","year":"2003","journal-title":"Nat Med"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib12","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1097\/00007890-199505270-00003","article-title":"Xenotransplantation of porcine and bovine islets without immunosuppression using uncoated alginate microspheres.","volume":"59","author":"Lanza","year":"1995","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib13","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI118929","article-title":"Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression.","volume":"98","author":"Sun","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib14","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0142-9612(99)00283-5","article-title":"Treatment of rat pancreatic islets with reactive PEG.","volume":"21","author":"Panza","year":"2000","journal-title":"Biomaterials"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib15","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/jbm.10246","article-title":"Optimization of monomethoxy-polyethylene glycol grafting on the pancreatic islet capsules.","volume":"62","author":"Lee","year":"2002","journal-title":"J Biomed Mater Res"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib16","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1016\/j.biomaterials.2003.10.062","article-title":"Immune reactions of lymphocytes and macrophages against PEG-grafted pancreatic islets.","volume":"25","author":"Lee","year":"2004","journal-title":"Biomaterials"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1163\/156856204774196144","article-title":"Effect of polyethylene glycol grafted onto islet capsules on prevention of splenocytes and cytokine attacks.","volume":"15","author":"Lee","year":"2004","journal-title":"J Biomater Sci Polym Ed"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib18","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.surg.2004.05.031","article-title":"A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets.","volume":"136","author":"Contreras","year":"2004","journal-title":"Surgery"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.biomaterials.2004.02.048","article-title":"Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation.","volume":"26","author":"Xie","year":"2005","journal-title":"Biomaterials"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib20","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1089\/ten.2006.12.615","article-title":"A new strategy toward improving immunoprotection in cell therapy for diabetes mellitus: Long-functioning PEGylated islets in vivo.","volume":"12","author":"Lee","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib21","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jconrel.2005.10.023","article-title":"A combination therapy of PEGylation and immunosuppressive agent for successful islet transplantation.","volume":"110","author":"Lee","year":"2006","journal-title":"J Control Release"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib22","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.2337\/diabetes.50.9.1983","article-title":"Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation","volume":"50","author":"Pileggi","year":"2001","journal-title":"Diabetes"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib23","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1210\/endo.139.10.6244","article-title":"A protective role for heme oxygenase expression in pancreatic islets exposed to interleukin-1b.","volume":"139","author":"Ye","year":"1998","journal-title":"Endocrinology"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib24","doi-asserted-by":"crossref","first-page":"566","DOI":"10.2310\/6650.2001.33721","article-title":"Heme oxygenase-1 protects pancreatic \u03b2 cells from apoptosis caused by various stimuli.","volume":"49","author":"Tobiasch","year":"2001","journal-title":"J Investig Med"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib25","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.61.2.748","article-title":"The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase","volume":"61","author":"Tenhunen","year":"1968","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nm0302-240","article-title":"Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice.","volume":"8","author":"Lee","year":"2002","journal-title":"Nat Med"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib27","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/2063","article-title":"Expression of heme oxygenase-1 can determine cardiac xenograft survival.","volume":"4","author":"Soare","year":"1998","journal-title":"Nat Med"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib28","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.4049\/jimmunol.166.6.4185","article-title":"Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplant.","volume":"166","author":"Sato","year":"2001","journal-title":"J Immunol"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib29","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1007\/BF00275748","article-title":"Assessment of islet cell viability using fluorescent dyes.","volume":"30","author":"Bank","year":"1987","journal-title":"Diabetologia"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib30","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1006\/bbrc.2000.2683","article-title":"Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells.","volume":"271","author":"Nakayama","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib31","doi-asserted-by":"crossref","first-page":"L312","DOI":"10.1152\/ajplung.2000.278.2.L312","article-title":"Heme oxygenase-1 inhibits TNF-\u03b1-induced apoptosis in cultured fibroblasts.","volume":"278","author":"Petrache","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/00007890-200209150-00001","article-title":"Inhibition of ischemia\/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1.","volume":"74","author":"Tullius","year":"2002","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s002040100253","article-title":"Heme oxygenase is the main protective enzyme in rat liver up to 6-day administration of cobalt chloride","volume":"75","author":"Christova","year":"2001","journal-title":"Arch Toxicol"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib34","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1097\/00007890-199405150-00001","article-title":"Mechanisms of T cell recognition of alloantigen. The role of peptides.","volume":"57","author":"Sayegh","year":"1994","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib35","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1084\/jem.179.3.865","article-title":"Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo.","volume":"179","author":"Lee","year":"1994","journal-title":"J Exp Med"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0169-409X(98)00023-4","article-title":"Host response to tissue engineered devices.","volume":"33","author":"Babensee","year":"1998","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib37","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiological importance.","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"10.1111\/j.1600-6143.2006.01414.x_bib38","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/74680","article-title":"Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway.","volume":"6","author":"Otterbein","year":"2000","journal-title":"Nat Med"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-6143.2006.01414.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522039636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522039636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-6143.2006.01414.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:39:23Z","timestamp":1761626363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522039636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S1600613522039636"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-6143.2006.01414.x","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Minimization of Immunosuppressive Therapy After Islet Transplantation: Combined Action of Heme Oxygenase-1 and PEGylation to Islet","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1600-6143.2006.01414.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}