{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:48:02Z","timestamp":1780080482731,"version":"3.54.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":5907,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1111\/j.1600-6143.2006.01478.x","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T06:45:21Z","timestamp":1157611521000},"page":"2256-2267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Increasing Resistance of Tubular Epithelial Cells to Apoptosis by shRNA Therapy Ameliorates Renal Ischemia-Reperfusion Injury"],"prefix":"10.1016","volume":"6","author":[{"given":"C.","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Jevnikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1600-6143.2006.01478.x_bib1","doi-asserted-by":"crossref","first-page":"F608","DOI":"10.1152\/ajprenal.00284.2002","article-title":"Cell death induced by acute renal injury: A perspective on the contributions of apoptosis and necrosis","volume":"284","author":"Padanilam","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/00041552-200205000-00006","article-title":"Role of apoptosis in the pathogenesis of acute renal failure","volume":"11","author":"Bonegio","year":"2002","journal-title":"Curr Opin Nephrol Hyperten"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00008480-200204000-00007","article-title":"Acute renal failure","volume":"14","author":"Andreoli","year":"2002","journal-title":"Curr Opin Pediatr"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib4","first-page":"505","article-title":"Necrosis and apoptosis in acute renal failure","volume":"18","author":"Lieberthal","year":"1998","journal-title":"Semin Nephrol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib5","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1681\/ASN.V94620","article-title":"Induction of apoptosis in ischemia-reperfusion model of mouse kidney: Possible involvement of Fas","volume":"9","author":"Nogae","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib6","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1097\/00007890-199903270-00003","article-title":"Involvement of endogenous interleukin-10 and tumor necrosis factor-alpha in renal ischemia-reperfusion injury","volume":"67","author":"Daemen","year":"1999","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00005392-199907000-00068","article-title":"The role of tumor necrosis factor in renal ischemia-reperfusion injury","volume":"162","author":"Donnahoo","year":"1999","journal-title":"J Urol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0092-8674(00)80572-3","article-title":"Solution structure of BID, an intracellular amplifier of apoptotic signaling","volume":"96","author":"Chou","year":"1999","journal-title":"Cell"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cellsig.2003.08.007","article-title":"Death receptor-induced cell killing","volume":"16","author":"Thorburn","year":"2004","journal-title":"Cell Signal"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.med.55.091902.104408","article-title":"Progress in antisense technology","volume":"55","author":"Crooke","year":"2004","journal-title":"Annu Rev Med"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1182\/blood.V91.2.371","article-title":"The therapeutic potential of ribozymes","volume":"91","author":"James","year":"1998","journal-title":"Blood"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib12","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1677\/jme.1.01582","article-title":"RNA interference and the use of small interfering RNA to study gene function in mammalian systems","volume":"33","author":"Bantounas","year":"2004","journal-title":"J Mol Endocrinol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib13","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1111\/j.1600-6143.2004.00530.x","article-title":"RNA interference: A potent tool for gene-specific therapeutics","volume":"4","author":"Ichim","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nm828","article-title":"RNA interference targeting Fas protects mice from fulminant hepatitis","volume":"9","author":"Song","year":"2003","journal-title":"Nat Med"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib15","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1073\/pnas.1330920100","article-title":"Caspase 8 small interfering RNA prevents acute liver failure in mice","volume":"100","author":"Zender","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib16","doi-asserted-by":"crossref","first-page":"14883","DOI":"10.1073\/pnas.0406421101","article-title":"Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury","volume":"101","author":"Hamar","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib17","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.surg.2004.05.015","article-title":"Caspase-8 and caspase-3 small interfering RNA decreases ischemia\/reperfusion injury to the liver in mice","volume":"136","author":"Contreras","year":"2004","journal-title":"Surgery"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/sj.gt.3302433","article-title":"Systemic administration of naked DNA with targeting specificity to mammalian kidneys","volume":"12","author":"Wu","year":"2005","journal-title":"Gene Ther"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ki.1991.201","article-title":"Stimulated kidney tubular epithelial cells express membrane associated and secreted TNF alpha","volume":"40","author":"Jevnikar","year":"1991","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib20","doi-asserted-by":"crossref","first-page":"F1044","DOI":"10.1152\/ajprenal.00341.2005","article-title":"Nitric oxide induces apoptosis in renal tubular epithelial cells (TEC) through activation of caspase-8","volume":"290","author":"Du","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/mthe.2000.0058","article-title":"A modular set of helper-dependent herpes simplex virus expression vectors","volume":"1","author":"Strathdee","year":"2000","journal-title":"Mol Ther"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib22","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1111\/j.1600-6143.2004.00552.x","article-title":"Renal tubular epithelial cell self-injury through Fas\/Fas ligand interaction promotes renal allograft injury","volume":"4","author":"Du","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib23","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.1523-1755.2005.00217.x","article-title":"IL-2-mediated apoptosis of kidney tubular epithelial cells is regulated by the caspase-8 inhibitor c-FLIP","volume":"67","author":"Du","year":"2005","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib24","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/00007890-199502270-00022","article-title":"Ischemic acute tubular necrosis induces an extensive local cytokine response: Evidence for induction of interferon-\u03b3, transforming growth factor-\u03b2 1, granulocyte-macrophage colony-stimulating factor, interleukin-2, and interleukin-10","volume":"59","author":"Goes","year":"1995","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00041552-199805000-00009","article-title":"Biology of ischemic and toxic renal tubular cell injury: Role of nitric oxide and the inflammatory response","volume":"7","author":"Lieberthal","year":"1998","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib26","doi-asserted-by":"crossref","first-page":"F948","DOI":"10.1152\/ajprenal.2001.281.5.F948","article-title":"Oxidative and nitrosative stress in acute renal ischemia","volume":"281","author":"Noiri","year":"2001","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib27","first-page":"1465","article-title":"In situ detection of fragmented DNA (tunnel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note","volume":"21","author":"Grasil-Kraupp","year":"1995","journal-title":"Hepatology"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib28","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1172\/JCI6974","article-title":"Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation","volume":"104","author":"Daemen","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib29","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1046\/j.1523-1755.1999.00701.x","article-title":"Cell survival or death in renal tubular epithelium after ischemia-reperfusion injury","volume":"56","author":"Gobe","year":"1999","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib30","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1681\/ASN.V1092006","article-title":"Apoptosis of tubular epithelial cells in donor kidney biopsies predicts early renal allograft function","volume":"10","author":"Oberbauer","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib31","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/00007890-199810150-00010","article-title":"Apoptosis in ischemia\/reperfusion injury of human renal allografts","volume":"66","author":"Burns","year":"1998","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1681\/ASN.V5112","article-title":"Apoptosis and the kidney","volume":"5","author":"Savill","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib33","first-page":"F315","article-title":"Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells","volume":"274","author":"Lieberthal","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0002-9343(00)00311-9","article-title":"Apoptotic mechanisms in acute renal failure","volume":"108","author":"Ueda","year":"2000","journal-title":"Am J Med"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib35","first-page":"F477","article-title":"Mechanisms of apoptosis and its potential role in renal tubular epithelial cell injury","volume":"271","author":"Lieberthal","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib36","first-page":"F837","article-title":"Partial ATP depletion induces Fas- and caspase-mediated apoptosis in MDCK cells","volume":"276","author":"Feldenberg","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib37","first-page":"F728","article-title":"Neutrophils accentuate ischemia-reperfusion injury in isolated perfused rat kidneys","volume":"255","author":"Linas","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib38","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/ki.1997.200","article-title":"Leukocytes, cell adhesion molecules and ischemic acute renal failure","volume":"51","author":"Rabb","year":"1997","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6","article-title":"Pathophysiology of ischaemia-reperfusion injury","volume":"190","author":"Carden","year":"2000","journal-title":"J Pathol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib40","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1523-1755.2004.761_11.x","article-title":"Long-term effects of acute ischemia and reperfusion injury","volume":"66","author":"Gueler","year":"2004","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib41","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.4049\/jimmunol.162.9.5506","article-title":"Ischemia\/reperfusion-induced IFN-gamma up-regulation: Involvement of IL-12 and IL-18","volume":"162","author":"Daemen","year":"1999","journal-title":"J Immunol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib42","first-page":"F383","article-title":"Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice","volume":"277","author":"Ling","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib43","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1046\/j.1523-1755.2003.00802.x","article-title":"GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia\/reperfusion injury","volume":"63","author":"Chatterjee","year":"2003","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib44","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1681\/ASN.V1171266","article-title":"Proapoptotic Fas ligand is expressed by normal kidney tubular epithelium and injured glomeruli","volume":"11","author":"Lorz","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib45","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1172\/JCI117214","article-title":"Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells","volume":"93","author":"Witzgall","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib46","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1172\/JCI22593","article-title":"Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells","volume":"115","author":"Duffield","year":"2005","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"10.1111\/j.1600-6143.2006.01478.x_bib47","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1097\/01.ASN.0000067652.51441.21","article-title":"Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure","volume":"14","author":"Bonventre","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1600-6143.2006.01478.x_bib48","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpgi.1999.276.1.G1","article-title":"Mechanisms of hepatic toxicity V. Necrapoptosis and the mitochondrial permeability transition: Shared pathways to necrosis and apoptosis","volume":"276","author":"Lemasters","year":"1999","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"5 Suppl","key":"10.1111\/j.1600-6143.2006.01478.x_bib49","doi-asserted-by":"crossref","first-page":"S235","DOI":"10.1097\/00003246-200205001-00011","article-title":"Endothelial injury and dysfunction in ischemic acute renal failure","volume":"30","author":"Molitoris","year":"2002","journal-title":"Crit Care Med"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-6143.2006.01478.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522028210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522028210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-6143.2006.01478.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:39:41Z","timestamp":1761626381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522028210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S1600613522028210"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-6143.2006.01478.x","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increasing Resistance of Tubular Epithelial Cells to Apoptosis by shRNA Therapy Ameliorates Renal Ischemia-Reperfusion Injury","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1600-6143.2006.01478.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}