{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:52:55Z","timestamp":1791341575547,"version":"4.3.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":5907,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1111\/j.1600-6143.2006.01493.x","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T06:45:21Z","timestamp":1157611521000},"page":"2292-2306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Connective Tissue Growth Factor is a Biomarker and Mediator of Kidney Allograft Fibrosis"],"prefix":"10.1016","volume":"6","author":[{"given":"O.","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Thuillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.T.","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.B.","family":"Mannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1600-6143.2006.01493.x_bib1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1600-6143.2004.00332.x","article-title":"Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era","volume":"4","author":"Meier-Kriesche","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib2","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1056\/NEJMoa020009","article-title":"The natural history of chronic allograft nephropathy","volume":"349","author":"Nankivell","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib3","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1046\/j.1523-1755.1999.00299.x","article-title":"The Banff 97 working classification of renal allograft pathology","volume":"55","author":"Racusen","year":"1999","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib4","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1056\/NEJMp038178","article-title":"Chronic allograft nephropathy","volume":"349","author":"Colvin","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00007890-200101270-00024","article-title":"Tubulitis after renal transplantation: Demonstration of an association between CD103+ T cells, transforming growth factor beta1 expression and rejection grade","volume":"71","author":"Robertson","year":"2001","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib6","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/ki.1996.185","article-title":"Intragraft TGF-beta 1 mRNA: A correlate of interstitial fibrosis and chronic allograft nephropathy","volume":"49","author":"Sharma","year":"1996","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib7","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1681\/ASN.V62286","article-title":"Transforming growth factor-beta and matrix protein expression in acute and chronic rejection of human renal allografts","volume":"6","author":"Shihab","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib8","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1046\/j.1523-1755.1999.00423.x","article-title":"Chronic rejection of mouse kidney allografts","volume":"55","author":"Mannon","year":"1999","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib9","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1038\/ki.1996.512","article-title":"Expression of TGF-beta 1 and matrix proteins is elevated in rats with chronic rejection","volume":"50","author":"Shihab","year":"1996","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib10","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1600-6143.2004.00713.x","article-title":"Epithelial-to-mesenchymal transition and oxidative stress in chronic allograft nephropathy","volume":"5","author":"Djamali","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib11","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/j.1600-6143.2005.00843.x","article-title":"Epithelial to mesenchymal transition during late deterioration of human kidney transplants: The role of tubular cells in fibrogenesis","volume":"5","author":"Vongwiwatana","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib12","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1111\/j.1600-6143.2006.01339.x","article-title":"Chronic allograft nephropathy: Intraepithelial signals generated by transforming growth factor-beta and bone morphogenetic protein-7","volume":"6","author":"Tyler","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib13","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/359693a0","article-title":"Targeted disruption of the mouse transforming growth factor-b1 gene results in multifocal inflammatory disease","volume":"359","author":"Shull","year":"1992","journal-title":"Nature"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/00007890-200207150-00019","article-title":"Retroviral delivery of transforming growth factor-beta1 to myeloid dendritic cells: Inhibition of T-cell priming ability and influence on allograft survival","volume":"74","author":"Takayama","year":"2002","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/00007890-200202270-00016","article-title":"High transforming growth factor-beta and extracellular matrix mRNA response in renal allografts during early acute rejection is associated with absence of chronic rejection","volume":"73","author":"Eikmans","year":"2002","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib16","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1097\/00007890-199704270-00009","article-title":"Sequential cellular and molecular kinetics in acutely rejecting renal allografts in rats","volume":"63","author":"Nagano","year":"1997","journal-title":"Transplantation"},{"issue":"5 Pt 1","key":"10.1111\/j.1600-6143.2006.01493.x_bib17","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1600-6143.2006.01261.x","article-title":"Therapeutic targets in the treatment of allograft fibrosis","volume":"6","author":"Mannon","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1359-6101(97)00010-5","article-title":"Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts","volume":"8","author":"Grotendorst","year":"1997","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib19","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1096\/fj.04-3217com","article-title":"Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation","volume":"19","author":"Grotendorst","year":"2005","journal-title":"FASEB J"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib20","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1681\/ASN.V123472","article-title":"Kinetics of connective tissue growth factor expression during experimental proliferative glomerulonephritis","volume":"12","author":"Ito","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib21","doi-asserted-by":"crossref","first-page":"F933","DOI":"10.1152\/ajprenal.00122.2001","article-title":"Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis","volume":"282","author":"Yokoi","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1523-1755.1998.00820.x","article-title":"Expression of connective tissue growth factor in human renal fibrosis","volume":"53","author":"Ito","year":"1998","journal-title":"Kidney Int"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib23","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1432-2277.2005.00113.x","article-title":"Cytomegalovirus enhance expression of growth factors during the development of chronic allograft nephropathy in rats","volume":"18","author":"Inkinen","year":"2005","journal-title":"Transpl Int"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1034\/j.1600-6143.2003.00081.x","article-title":"Inhibition of prolyl-4-hydroxylase ameliorates chronic rejection of mouse kidney allografts","volume":"3","author":"Franceschini","year":"2003","journal-title":"Am J Transplant"},{"issue":"5 Pt 1","key":"10.1111\/j.1600-6143.2006.01493.x_bib25","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1600-6143.2006.01292.x","article-title":"Transforming growth factor beta-induced connective tissue growth factor and chronic allograft rejection","volume":"6","author":"Csencsits","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib26","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1097\/00007890-199503150-00019","article-title":"Rejection of kidney allografts by MHC class I-deficient mice","volume":"59","author":"Mannon","year":"1995","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib27","doi-asserted-by":"crossref","first-page":"F1116","DOI":"10.1152\/ajprenal.00366.2003","article-title":"A simplified method for HPLC determination of creatinine in mouse serum","volume":"286","author":"Yuen","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib28","doi-asserted-by":"crossref","first-page":"F1344","DOI":"10.1152\/ajprenal.00174.2005","article-title":"Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF\/CCN-2) in diabetic nephropathy in mice","volume":"290","author":"Roestenberg","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib29","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1006\/bbrc.1998.9543","article-title":"Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia","volume":"251","author":"Tamatani","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib30","doi-asserted-by":"crossref","first-page":"F1044","DOI":"10.1152\/ajprenal.00341.2005","article-title":"Nitric oxide induces apoptosis in renal tubular epithelial cells through activation of caspase-8","volume":"290","author":"Du","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib31","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1593\/neo.04241","article-title":"Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro","volume":"6","author":"Xie","year":"2004","journal-title":"Neoplasia"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib32","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1210\/endo.140.11.7108","article-title":"Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood","volume":"140","author":"Atanassova","year":"1999","journal-title":"Endocrinology"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib33","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.2337\/diacare.27.5.1164","article-title":"Connective tissue growth factor is increased in plasma of type 1 diabetic patients with nephropathy","volume":"27","author":"Roestenberg","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib34","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.2337\/diacare.26.9.2632","article-title":"Urinary connective tissue growth factor excretion in patients with type 1 diabetes and nephropathy","volume":"26","author":"Gilbert","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib35","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/00007890-200210150-00003","article-title":"Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury","volume":"74","author":"Hoffmann","year":"2002","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib36","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1600-6143.2005.00719.x","article-title":"Functionally significant renal allograft rejection is defined by transcriptional criteria","volume":"5","author":"Hoffmann","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib37","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1111\/j.1600-6143.2005.01096.x","article-title":"Molecular evaluation of BK polyomavirus nephropathy","volume":"5","author":"Mannon","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib38","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1097\/00007890-200005270-00031","article-title":"Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts","volume":"69","author":"Mannon","year":"2000","journal-title":"Transplantation"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1681\/ASN.V101167","article-title":"Rethinking chronic allograft nephropathy: The concept of accelerated senescence","volume":"10","author":"Halloran","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1056\/NEJM200107123450203","article-title":"Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection","volume":"345","author":"Grimm","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib41","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1093\/ndt\/gfh967","article-title":"Cyclosporine A induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells","volume":"20","author":"McMorrow","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib42","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0002-9440(10)62984-7","article-title":"Cyclosporine A-induced renal fibrosis: A role for epithelial-mesenchymal transition","volume":"167","author":"Slattery","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib43","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/01.ASN.0000108521.39082.E1","article-title":"Chronic renal allograft dysfunction: The role of T cell-mediated tubular epithelial to mesenchymal cell transition","volume":"15","author":"Robertson","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib44","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0002-9440(10)63659-0","article-title":"Angiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways","volume":"163","author":"Finckenberg","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib45","doi-asserted-by":"crossref","first-page":"F1223","DOI":"10.1152\/ajprenal.00245.2004","article-title":"Hypoxic induction of CTGF is directly mediated by Hif-1","volume":"287","author":"Higgins","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib46","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1172\/JCI1229","article-title":"Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts","volume":"101","author":"Mannon","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib47","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/17401","article-title":"Cyclosporine induces cancer progression by a cell-autonomous mechanism","volume":"397","author":"Hojo","year":"1999","journal-title":"Nature"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib48","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1067-1927.2004.012113.x","article-title":"Connective tissue growth factor siRNA modulates mRNA levels for a subset of molecules in normal and TGF-beta 1-stimulated porcine skin fibroblasts","volume":"12","author":"Wang","year":"2004","journal-title":"Wound Repair Regen"},{"key":"10.1111\/j.1600-6143.2006.01493.x_bib49","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1097\/01.ASN.0000130565.69170.85","article-title":"Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis","volume":"15","author":"Yokoi","year":"2004","journal-title":"J Am Soc Nephrol"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-6143.2006.01493.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522028246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613522028246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-6143.2006.01493.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:38:27Z","timestamp":1761626307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613522028246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S1600613522028246"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-6143.2006.01493.x","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Connective Tissue Growth Factor is a Biomarker and Mediator of Kidney Allograft Fibrosis","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/j.1600-6143.2006.01493.x","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}