{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T04:43:09Z","timestamp":1768538589611,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,8,30]],"date-time":"2005-08-30T00:00:00Z","timestamp":1125360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p><jats:bold>Abstract\u2002\u2013\u2002<\/jats:bold> The purpose of this study was to evaluate the potential of alendronate sodium (ALN), a biphosohonate to stimulate hard tissue formation in pulpotomized (amputated) rat molars. Two commonly used pulpotomy materials, calcium hydroxide (CH) and formocresol (FC) were utilized for comparisons. Histological evaluations were performed by observers blinded to treatment allocation on days 7, 15, 30 and 60, followed by statistical analysis of selected histological criteria. In all evaluation periods, hard tissue deposition was evident along the radicular dentin in ALN and CH groups. In days 30 and 60, the latter two groups showed no differences in inflammatory cell response and hard tissue deposition scores (<jats:italic>P<\/jats:italic>\u2003&gt;\u20030.05). ALN appears to be capable of maintaining pulpal vitality, while promoting hard tissue formation, similar to CH.<\/jats:p>","DOI":"10.1111\/j.1600-9657.2005.00325.x","type":"journal-article","created":{"date-parts":[[2005,8,30]],"date-time":"2005-08-30T15:45:59Z","timestamp":1125416759000},"page":"281-288","source":"Crossref","is-referenced-by-count":8,"title":["Histological comparison of alendronate, calcium hydroxide and formocresol in amputated rat molar"],"prefix":"10.1111","volume":"21","author":[{"given":"S.","family":"Burcak Cengiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yildiz","family":"Batirbaygil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"Onur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pergin","family":"Atilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esin","family":"Asan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nil","family":"Altay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafer C.","family":"Cehreli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,30]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"416","article-title":"Pulpotomy medicaments for vital primary teeth","volume":"56","author":"Avram DC","year":"1989","journal-title":"ASDC J Dent Child"},{"key":"e_1_2_5_3_2","first-page":"118","article-title":"Primary tooth pulp therapy as taught in predoctoral pediatric dental programs in the United States","volume":"19","author":"Primosch RE","year":"1997","journal-title":"Pediatr Dent"},{"key":"e_1_2_5_4_2","first-page":"431","article-title":"Assessment of the systemic distribution and toxicity of formaldehyde following pulpotomy treatment: part one","volume":"5","author":"Ranly DM.","year":"1985","journal-title":"ASDC J Dent Child"},{"key":"e_1_2_5_5_2","first-page":"429","article-title":"Formaldehyde in dentistry: a review of mutagenic and carcinogenic potential","volume":"103","author":"Lewis BB","year":"1987","journal-title":"JADA"},{"key":"e_1_2_5_6_2","first-page":"403","article-title":"Pulpotomy in primary teeth: new modalities for old rationales","volume":"16","author":"Ranly DM.","year":"1994","journal-title":"Pediatr Dent"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(99)00065-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(81)90366-2"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00413.x"},{"key":"e_1_2_5_10_2","first-page":"400","article-title":"Healing of pulp exposures: an ultrastructural study","volume":"192","author":"Mjor IA","year":"1991","journal-title":"J Anat"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115539"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.9.884"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5.790"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.10.1228"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2001.017003120.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200301000-00008"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200003000-00001"},{"key":"e_1_2_5_18_2","first-page":"81","article-title":"Pulp response to direct capping with an adhesive system","volume":"13","author":"Costa CAS","year":"2000","journal-title":"Am J Dent"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263x.2000.00211.x"},{"key":"e_1_2_5_20_2","first-page":"430","article-title":"Radiographic evaluation of root canal \u2018calcification\u2019 following formocresol pulpotomy","volume":"50","author":"Garcia\u2010Godoy F.","year":"1983","journal-title":"ASDC J Dent Child"},{"key":"e_1_2_5_21_2","first-page":"247","article-title":"Pulpal tissue reaction to formocresol vs. ferric sulfate in pulpotomized rat teeth","volume":"21","author":"Cotes O","year":"1997","journal-title":"J Clin Pediatr Dent"},{"key":"e_1_2_5_22_2","first-page":"17","article-title":"Criteia for standardizing and increasing credibility of direct pulp capping studies","volume":"11","author":"Stanley HR.","year":"1998","journal-title":"Am J Dent"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/002203458506400414"},{"issue":"1","key":"e_1_2_5_24_2","first-page":"S230","article-title":"Biphosphonates inhibit IL\u20106 production by human osteoblastic cells MG\u201063 (Abstract)","volume":"9","author":"Passeri G","year":"1994","journal-title":"J Bone Miner Res"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.66.25"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200003000-00001"}],"container-title":["Dental Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-9657.2005.00325.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-9657.2005.00325.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T12:10:13Z","timestamp":1697026213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-9657.2005.00325.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,30]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1111\/j.1600-9657.2005.00325.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-9657.2005.00325.x","archive":["Portico"],"relation":{},"ISSN":["1600-4469","1600-9657"],"issn-type":[{"value":"1600-4469","type":"print"},{"value":"1600-9657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,30]]}}}