{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:27:26Z","timestamp":1780475246661,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T00:00:00Z","timestamp":1236297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p><jats:bold>Abstract\u2002\u2013\u2002<\/jats:bold> This study evaluated periapical tissue healing and orthodontic root resorption of endodontically treated teeth sealed with calcium hydroxide in dogs. The sample consisted of three contralateral pairs of maxillary incisors and two contralateral pairs of mandibular incisors in each of two dogs using a split mouth design. After biomechanical preparation of the teeth in the first group (<jats:italic>n<\/jats:italic>\u2003=\u200310), a Ca(OH)<jats:sub>2<\/jats:sub> dressing was placed for 14\u2003days before root canal filling with Ca(OH)<jats:sub>2<\/jats:sub>\u2010based sealer (Sealapex) and gutta\u2010percha points. In the second group (<jats:italic>n<\/jats:italic>\u2003=\u200310), root canals were obturated immediately after the mechanical preparation with gutta\u2010percha points and zinc oxide and eugenol (ZOE)\u2010based sealer (Endofill). After completion of endodontic treatment, the teeth were moved with an orthodontic appliance with a calibrated force of 200\u2003g, reactivated every 21\u2003days. After 105\u2003days, the animals were killed and the teeth were removed upon completion of active treatment, without a period of recovery, and prepared for histomorphological analysis. All sections of each tooth were graded subjectively on a scale from one to four to obtain the average of the 16 histomorphological parameters analysed. Evaluation of the differences between the two treatment protocols was made with Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test. It was observed that the teeth treated with Ca(OH)<jats:sub>2<\/jats:sub>\u2010based materials provided better outcomes (<jats:italic>P<\/jats:italic>\u2003=\u20035%), with complete repair of all root resorption areas, high rate of biological closure of the main canal and apical accessory canals by newly formed cementum, less intense and extensive chronic inflammatory infiltrate, and better organization of the periodontal ligament. Under the tested conditions, Ca(OH)<jats:sub>2<\/jats:sub>\u2010based materials had a favourable action on periapical tissue healing and repair of orthodontic root resorption in endodontically treated dogs\u2019 teeth.<\/jats:p>","DOI":"10.1111\/j.1600-9657.2008.00758.x","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T07:45:38Z","timestamp":1236325538000},"page":"213-218","source":"Crossref","is-referenced-by-count":17,"title":["Effect of calcium hydroxide\u2010based materials on periapical tissue healing and orthodontic root resorption of endodontically treated teeth in dogs"],"prefix":"10.1111","volume":"25","author":[{"given":"Ricardo Sampaio","family":"De Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir","family":"De 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