{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:54:23Z","timestamp":1790571263689,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T00:00:00Z","timestamp":1318291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:bold>Abstract \u2013\u2002<\/jats:bold> Background:\u2002Non\u2010setting calcium hydroxide (Ultracal XS<jats:sup>\u00ae<\/jats:sup>) is recommended by the International Association of Dental Traumatology as the initial medicament following avulsion and replantation for mature teeth. There is experimental evidence to suggest Ledermix<jats:sup>\u00ae<\/jats:sup>, placed as an alternative inter\u2010visit dressing may improve periodontal healing. Aim:\u2002This study investigated, using a multi\u2010centre randomized controlled trial, the effect of two root canal medicaments, Ledermix<jats:sup>\u00ae<\/jats:sup> and Ultracal XS<jats:sup>\u00ae<\/jats:sup>, on periodontal healing of avulsed and replanted teeth. Material and methods:\u2002Children were recruited if they fulfilled all inclusion criteria. Treatment followed a standardized protocol. Assessment of periodontal healing or ankylosis was made clinically and radiographically by an experienced, \u2018blinded\u2019, clinician at 12\u2003months. Results:\u2002Over 200 patients were assessed for eligibility at five centres. Twenty\u2010nine patients were eligible for inclusion. Final analysis involved 22 patients with 27 teeth. Ankylosis was detected in four of the 12 teeth in the Ledermix<jats:sup>\u00ae<\/jats:sup> group and nine of 15 in the Ultracal XS<jats:sup>\u00ae<\/jats:sup> group. No significant difference between medicaments was found in the proportion of teeth or patients showing periodontal healing. Discussion:\u2002There was no significant difference in periodontal healing between the two medicaments at either a tooth or patient level. The numbers recruited fell short of an estimated power calculation. For patients meeting the inclusion criteria and completing the trial, periodontal healing was seen in 52% of teeth at the 12\u2010month assessment between both groups. The only factor found to significantly influence the periodontal outcome was dry time.<\/jats:p>","DOI":"10.1111\/j.1600-9657.2011.01053.x","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T11:58:44Z","timestamp":1318334324000},"page":"55-64","source":"Crossref","is-referenced-by-count":42,"title":["Periodontal healing following avulsion and replantation of teeth: a multi\u2010centre randomized controlled trial to compare two root canal medicaments"],"prefix":"10.1111","volume":"28","author":[{"given":"Peter F.","family":"Day","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry A.","family":"Gregg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Welbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben O.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec S.","family":"High","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monty S.","family":"Duggal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,11]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"444","volume-title":"Textbook and color atlas of traumatic injuries to the teeth","author":"Andreasen JO","year":"2007"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1995.tb00464.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4800740a"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1997.tb00054.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006542.pub2"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2007.00605.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263X.1998.00066.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1990.tb00413.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1990.tb00412.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(81)80095-7"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1988.tb00295.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1995.tb00462.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1986.tb00132.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(81)80056-8"},{"key":"e_1_2_7_16_2","first-page":"139","article-title":"Effect of immediate calcium hydroxide treatment and permanent root\u2010filling on periodontal healing in contaminated replanted teeth","volume":"99","author":"Lengheden A","year":"1990","journal-title":"Scand J Dent Res"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2001.170603.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2002.00142.x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2006.00483.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(87)90094-6"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2002.00137.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2005.00330.x"},{"key":"e_1_2_7_23_2","unstructured":"CONSORT Group.CONSORT statement.http:\/\/www.consort\u2010statement.org\/indexaspx?o=1077(2010)."},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2001.170501.x"},{"key":"e_1_2_7_25_2","first-page":"423","article-title":"Tooth ankylosis. Clinical, radiographic and histological assessments","volume":"13","author":"Andersson L","year":"1984","journal-title":"Int J Oral Maxillofac Surg"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1999.tb00786.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.04.014"},{"key":"e_1_2_7_28_2","first-page":"273","article-title":"Histometric study of root resorption on human premolars following experimental replantation","volume":"95","author":"Breivik M","year":"1987","journal-title":"Scand J Dent Res"},{"key":"e_1_2_7_29_2","first-page":"175","article-title":"Orthodontically induced inflammatory root resorption. Part 1: The basic science aspects","volume":"72","author":"Brezniak N","year":"2002","journal-title":"Angle Orthod"},{"key":"e_1_2_7_30_2","first-page":"101","article-title":"A time related study of periodontal healing and root resorption activity after replantation of mature permanent incisors in monkeys","volume":"4","author":"Andreasen JO","year":"1980","journal-title":"Swed Dent J"},{"key":"e_1_2_7_31_2","first-page":"557","article-title":"The effect of different splinting times on replantation of teeth in monkeys","volume":"53","author":"Nasjleti CE","year":"1982","journal-title":"J Oral Maxillofac Surg"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-1546.2002.20104.x"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-4469.2004.00235.x"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2002.00097.x"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2005.10.014"},{"key":"e_1_2_7_36_2","volume-title":"A guide to patient recruitment and retention","author":"Anderson DL","year":"2004"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(89)90010-1"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2009.00818.x"},{"key":"e_1_2_7_39_2","first-page":"308","article-title":"Avulsions and intrusions: the controversial displacement injuries","volume":"69","author":"Kenny DJ","year":"2003","journal-title":"J Can Dent Assoc"}],"container-title":["Dental Traumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-9657.2011.01053.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-9657.2011.01053.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:28:12Z","timestamp":1698737292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-9657.2011.01053.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,11]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.1600-9657.2011.01053.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-9657.2011.01053.x","archive":["Portico"],"relation":{},"ISSN":["1600-4469","1600-9657"],"issn-type":[{"value":"1600-4469","type":"print"},{"value":"1600-9657","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,11]]}}}