{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:48:28Z","timestamp":1793774908381,"version":"4.6.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T00:00:00Z","timestamp":1320278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:bold>Abstract\u2002\u2013\u2002<\/jats:bold> The prognosis for a reimplanted tooth depends largely on the condition of the root. Platelet\u2010derived growth factor (PDGF)\u2010BB has been shown to regenerate periodontal tissue in animal and human clinical studies. However, information regarding the effect of PDGF\u2010BB on tooth reimplantation is limited. The objective of this study was to investigate the effect of PDGF\u2010BB on root resorption after reimplantation of a partially denuded tooth in dog. A total of 15 healthy female beagle dogs were used. Mandibular third and fourth premolars were endodontically treated and then extracted as atraumatically as possible. The coronal portion of each root was carefully scaled and planed. The roots on the right side of the mandible were treated with PDGF\u2010BB and reimplanted, while the roots on the left side served as controls. After 2, 4, or 8\u2003weeks, specimens were collected and processed for histopathological examination. By the 4th week after reimplantation, new periodontal ligament (PDL)\u2010like tissue had formed around the PDGF\u2010BB\u2010treated root surfaces and new bone. By the 8th week, healing of the PDGF\u2010BB\u2010treated roots was characterized by newly formed PDL with inserting attachment formation. In contrast, control roots showed multiple areas of replacement resorption. Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) performed at 2\u2003weeks after reimplantation showed that the number of PCNA\u2010positive cells in the connective tissue area was statistically significantly greater in the PDGF\u2010BB\u2010treated group than in the control group (<jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001). The application of PDGF\u2010BB resulted in a significantly lower occurrence and extent of root resorption and ankylosis. These results suggest that the use of PDGF\u2010BB reduces occurrence of ankylosis and root resorption in tooth reimplantation.<\/jats:p>","DOI":"10.1111\/j.1600-9657.2011.01070.x","type":"journal-article","created":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T03:46:24Z","timestamp":1320378384000},"page":"217-225","source":"Crossref","is-referenced-by-count":7,"title":["Effect of platelet\u2010derived growth factor\u2010BB on root resorption after reimplantation of partially denuded tooth in 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