{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:54:22Z","timestamp":1790571262799,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T00:00:00Z","timestamp":1327449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Traumatology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>Abstract\u2002\u2013\u2002<\/jats:bold> The release and diffusion of hydroxyl ions (OH<jats:sup>\u2212<\/jats:sup>) of calcium hydroxide (Ca(OH)<jats:sub>2<\/jats:sub>)\u2010based intracanal medications may be affected by the association with other substances. The aim of this study was to evaluate the diffusion of OH\u2212 ions through root dentin by the medications: G1, Ca(OH)<jats:sub>2<\/jats:sub>\/saline; G2, Calen; G3, Calen\/camphorated p\u2010monochlorophenol (CMCP); and G4, Calen\/0.4% chlorhexidine (CHX). Root canals from bovine teeth were prepared in a standardized manner. A cavity until dentin was prepared in the middle third of the root surface of each specimen. The external surface of the root was made impermeable using a layer of adhesive, except the prepared cavity. The root canals were filled with different medications, and teeth were individually stored in flasks containing 10\u2003ml distilled water at 37\u00b0C. The water pH was measured at 1, 3, 7, 14, 21, 30, and 60\u2003days. Data obtained were subjected to <jats:sc>anova<\/jats:sc> and Tukey\u2019s tests. Increase in pH was observed at 3\u2003days for Calen\/CHX and from 7 to 14\u2003days for the other mixtures. Calen paste promoted pH increase up to 21\u2003days. Calen\/CMCP had the highest pH up to 21\u2003days, and all groups had similar results at 30\u2003days. At 60\u2003days, the greatest pH values were observed for Calen\/CMCP and Calen alone. All different formulations of Ca(OH)<jats:sub>2<\/jats:sub>\u2010based medications tested release hydroxyl ion that can diffuse through the dentin.<\/jats:p>","DOI":"10.1111\/j.1600-9657.2011.01112.x","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T05:44:16Z","timestamp":1327470256000},"page":"320-323","source":"Crossref","is-referenced-by-count":25,"title":["Release and diffusion of hydroxyl ion from calcium hydroxide\u2010based medicaments"],"prefix":"10.1111","volume":"28","author":[{"given":"Juliane Maria","family":"Guerreiro\u2010Tanomaru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Guidette","family":"Chula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina Karla","family":"de Pontes Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Luis Vilela 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